Author, as appears in the article.: Torres-Fuentes, Cristina; Suarez, Manuel; Aragones, Gerard; Mulero, Miquel; Avila-Roman, Javier; Arola-Arnal, Anna; Josepa Salvado, Maria; Arola, Lluis; Isabel Bravo, Francisca; Muguerza, Begona;

Department: Bioquímica i Biotecnologia

URV's Author/s: Arola Arnal, Anna / Arola Ferrer, Luis Maria / Ávila Román, Francisco Javier / Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / Mulero Abellán, Miguel / Salvadó Rovira, Maria Josepa / Suárez Recio, Manuel / Torres Fuentes, Cristina

Keywords: Red wine Pomegranate fruit extract Polyphenols Oxidative stress Oxidation-sensitive genes Nitric-oxide synthase Metabolic syndrome Insulin-resistance High-fat diet Grape seed proanthocyanidins Endothelial function Circadian rhythms Circadian clock Cardiovascular diseases Blood-pressure

Abstract: Cardiovascular diseases (CVD) are the leading cause of deaths worldwide and their prevalence is continuously increasing. Available treatments may present several side effects and therefore the development of new safer therapeutics is of interest. Phenolic compounds have shown several cardioprotective properties helpful in reducing different CVD risk factors such as inflammation, elevated blood pressure, hyperlipidemia, or endothelial dysfunction. These factors are significantly influenced by biological rhythms which are in fact emerging as key modulators of important metabolic and physiological processes. Thus, increased events of CVD have been observed under circadian rhythm disruption or in winter versus other seasons. These rhythms can also affect the functionality of phenolic compounds. Indeed, different effects have been observed depending on the administration time or under different photoperiods. Therefore, in this review the focus will be on the potential of phenolic compounds as therapeutics to prevent CVD via biological rhythm modulation.

Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: cristina.torres@urv.cat franciscojavier.avila@urv.cat franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat lluis.arola@urv.cat mariajosepa.salvado@urv.cat anna.arola@urv.cat miquel.mulero@urv.cat manuel.suarez@urv.cat

Author identifier: 0000-0002-2917-6910 0000-0001-9766-8178 0000-0002-6468-3088 0000-0001-7384-8588 0000-0003-2767-1974 0000-0003-3883-3326 0000-0001-6529-1345 0000-0003-0122-8253

Record's date: 2023-02-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100990

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecular Nutrition & Food Research. 66 (21): e2100990-

APA: Torres-Fuentes, Cristina; Suarez, Manuel; Aragones, Gerard; Mulero, Miquel; Avila-Roman, Javier; Arola-Arnal, Anna; Josepa Salvado, Maria; Arola, Llui (2022). Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms. Molecular Nutrition & Food Research, 66(21), e2100990-. DOI: 10.1002/mnfr.202100990

Article's DOI: 10.1002/mnfr.202100990

Entity: Universitat Rovira i Virgili

Journal publication year: 2022

Publication Type: Journal Publications