Author, as appears in the article.: Jalsevac, Florijan; Terra, Ximena; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Maria Teresa; Pinent, Montserrat; Ardevol, Anna
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Jalsevac, Florijan / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
Project code: Grant agreement No. 945413
Keywords: Taste buds Taste Tas2r39 antagonist Tas2r39 agonist Tas2r39 Respiratory system Receptors, g-protein-coupled Gpcr Gastrointestinal tract Food intake Catechin Bitter taste Animals
Abstract: Over thousands of years of evolution, animals have developed many ways to protect themselves. One of the most protective ways to avoid disease is to prevent the absorption of harmful components. This protective function is a basic role of bitter taste receptors (TAS2Rs), a G protein-coupled receptor family, whose presence in extraoral tissues has intrigued many researchers. In humans, there are 25 TAS2Rs, and although we know a great deal about some of them, others are still shrouded in mystery. One in this latter category is bitter taste receptor 39 (TAS2R39). Besides the oral cavity, it has also been found in the gastrointestinal tract and the respiratory, nervous and reproductive systems. TAS2R39 is a relatively non-selective receptor, which means that it can be activated by a range of mostly plant-derived compounds such as theaflavins, catechins and isoflavones. On the other hand, few antagonists for this receptor are available, since only some flavones have antagonistic properties (all of them detailed in the document). The primary role of TAS2R39 is to sense the bitter components of food and protect the organism from harmful compounds. There is also some indication that this bitter taste receptor regulates enterohormones and in turn, regulates food intake. In the respiratory system, it may be involved in the congestion process of allergic rhinitis and may stimulate inflammatory cytokines. However, more thorough research is needed to determine the precise role of TAS2R39 in these and other tissues.
Thematic Areas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Record's date: 2024-10-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fendo.2022.854718/full
Funding program: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Frontiers In Endocrinology. 13 854718-
APA: Jalsevac, Florijan; Terra, Ximena; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Maria Teresa; Pinent, Montserrat; Ardevol, Anna (2022). The Hidden One: What We Know About Bitter Taste Receptor 39. Frontiers In Endocrinology, 13(), 854718-. DOI: 10.3389/fendo.2022.854718
Acronym: MFP-Plus
Article's DOI: 10.3389/fendo.2022.854718
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Funding program action: Martí i Franquès COFUND Doctoral Programme
Publication Type: Journal Publications