Real-world outcomes of a clinical decision support system for diabetic retinopathy in Spain

Identifier:  imarina:9261219

Handle: https://hdl.handle.net/20.500.11797/imarina9261219

Authors:  Romero-Aroca, Pedro; Verges, Raquel; Maarof, Najlaa; Vallas-Mateu, Aida; Latorre, Alex; Moreno-Ribas, Antonio; Sagarra-Alamo, Ramon; Basora-Gallisa, Josep; Cristiano, Julian; Baget-Bernaldiz, Marc

Abstract:
Objective The aim of present study was to evaluate our clinical decision support system (CDSS) for predicting risk of diabetic retinopathy (DR). We selected randomly a real population of patients with type 2 diabetes (T2DM) who were attending our screening programme.Methods and analysis The sample size was 602 patients with T2DM randomly selected from those who attended the DR screening programme. The algorithm developed uses nine risk factors: current age, sex, body mass index (BMI), duration and treatment of diabetes mellitus (DM), arterial hypertension, Glicated hemoglobine (HbA1c), urine-albumin ratio and glomerular filtration.Results The mean current age of 67.03 +/- 10.91, and 272 were male (53.2%), and DM duration was 10.12 +/- 6.4 years, 222 had DR (35.8%). The CDSS was employed for 1 year. The prediction algorithm that the CDSS uses included nine risk factors: current age, sex, BMI, DM duration and treatment, arterial hypertension, HbA1c, urine-albumin ratio and glomerular filtration. The area under the curve (AUC) for predicting the presence of any DR achieved a value of 0.9884, the sensitivity of 98.21%, specificity of 99.21%, positive predictive value of 98.65%, negative predictive value of 98.95%, alpha error of 0.0079 and beta error of 0.0179.Conclusion Our CDSS for predicting DR was successful when applied to a real population.