Author, as appears in the article.: Badia-Cebada L; Peñafiel J; López-Contreras J; Pomar V; Martínez JA; Santana G; Cuquet J; Montero MM; Hidalgo-López C; Andrés M; Gimenez M; Quesada MD; Vaqué M; Iftimie S; Gudiol C; Pérez R; Coloma A; Marron A; Barrufet P; Marimon M; Lérida A; Clarós M; Ramírez-Hidalgo MF; Garcia Pardo G; Martinez MJ; Chamarro EL; Jiménez-Martínez E; Hornero A; Limón E; López M; Calbo E; Pujol M; Gasch O
Department: Medicina i Cirurgia
URV's Author/s: Iftimie Iftimie, Simona Mihaela
Keywords: Risk-factors Mortality Intervention programme Intervention program Healthcare-associated infection Catheter-related bloodstream infections Catheter-related bloodstream infection surveillance prevention multimodal intervention microbiology intervention programme impact icu healthcare-associated infection costs catheter-related bloodstream infection care
Abstract: The incidence of catheter-related bloodstream infections (CRBSI) has fallen over the last decade, especially in intensive care units (ICUs).To assess the existence of concomitant trends in outcomes and to analyse the current risk factors for mortality.A multicentre retrospective cohort study was conducted at 24 Catalan hospitals participating in the Surveillance of healthcare associated infections in Catalonia (VINCat). All hospital-acquired CRBSI episodes diagnosed from January 2010 to December 2019 were included. A common protocol including epidemiological, clinical and microbiological data was prospectively completed. Mortality at 30 days after bacteraemia onset was analysed using the Cox regression model.Over the study period, 4,795 episodes of CRBSI were diagnosed. Among them, 75% were acquired in conventional wards and central venous catheters were the most frequently involved (61%). The 30-day mortality rate was 13.8%, presenting a significant downward trend over the study period: from 17.9% in 2010 to 10.6% in 2019 (HR 0.95 [0.92-0.98]). The multivariate analysis identified age (HR 1.03 [1.02-1.04]), femoral catheter (HR 1.78 [1.33-2.38]), medical ward acquisition (HR 2.07 [1.62-2.65] and ICU acquisition (HR 3.45 [2.7-4.41]), S. aureus (HR 1.59 [1.27-1.99]) and Candida sp. (HR 2.19 [1.64-2.94]) as risk factors for mortality while the mortality rate associated with episodes originating in peripheral catheters was significantly lower (HR 0.69 [0.54-0.88]).Mortality associated with CRBSI has fallen in recent years but remains high. Intervention programs should focus especially on ICUs and medical wards, where incidence and mortality rates are highest.Copyright © 2022 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Thematic Areas: Saúde coletiva Química Public, environmental & occupational health Odontología Microbiology (medical) Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas i Ciências agrárias i Biotecnología Biodiversidade
Author's mail: simonamihaela.iftime@urv.cat
Author identifier: 0000-0003-0714-8414
Record's date: 2024-08-24
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Hospital Infection. 126 70-77
APA: Badia-Cebada L; Peñafiel J; López-Contreras J; Pomar V; Martínez JA; Santana G; Cuquet J; Montero MM; Hidalgo-López C; Andrés M; Gimenez M; Quesada MD (2022). Decreased Mortality among Patients with Catheter-Related Bloodstream Infections at Catalan Hospitals (2010-2019). Journal Of Hospital Infection, 126(), 70-77. DOI: 10.1016/j.jhin.2022.05.009
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV