Author, as appears in the article.: Jimenez, David; Rodriguez, Carmen; Leon, Francisco; Jara-Palomares, Luis; Lopez-Reyes, Raquel; Ruiz-Artacho, Pedro; Elias, Teresa; Otero, Remedios; Garcia-Ortega, Alberto; Rivas-Guerrero, Agustina; Abelaira, Jaime; Jimenez, Sonia; Muriel, Alfonso; Morillo, Raquel; Barrios, Deisy; Le Mao, Raphael; Yusen, Roger D.; Bikdeli, Behnood; Monreal, Manuel; Luis Lobo, Jose;IPEP Investigators
Department: Medicina i Cirurgia
URV's Author/s: Porras Ledantes, Jose Antonio
Keywords: Outpatient Mortality Early mobilization Costs Burden
Abstract: Background The length of hospital stay (LOS) for acute pulmonary embolism (PE) varies considerably. Whether the upfront use of a PE prognostic assessment and management pathway is effective in reducing the LOS remains unknown.Methods We conducted a randomised controlled trial of adults hospitalised for acute PE: patients were assigned either to a prognostic assessment and management pathway involving risk stratification followed by predefined criteria for mobilisation and discharge (intervention group) or to usual care (control group). The primary end-point was LOS. The secondary end-points were the cost of prognostic tests and of hospitalisation, and 30-day clinical outcomes.Results Of 500 patients who underwent randomisation, 498 were included in the modified intention-to-treat analysis. The median LOS was 4.0 days (interquartile range (IQR) 3.7-4.2 days) in the intervention group and 6.1 days (IQR 5.7-6.5 days) in the control group (p<0.001). The mean total cost of prognostic tests was EUR 174.76 in the intervention group, compared with EUR 233.12 in the control group (mean difference EUR -58.37, 95% CI EUR -84.34 to -32.40). The mean total hospitalisation cost per patient was EUR 2085.66 in the intervention group, compared with EUR 3232.97 in the control group (mean difference EUR -1147.31, 95% CI EUR -1414.97 to -879.65). No significant differences were observed in 30-day readmission (4.0% versus 4.8%), all-cause mortality (2.4% versus 2.0%) or PE-related mortality (0.8% versus 1.2%) rates.Conclusions The use of a prognostic assessment and management pathway was effective in reducing the LOS for acute PE.
Thematic Areas: Saúde coletiva Respiratory system Pulmonary and respiratory medicine Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: joseantonio.porras@urv.cat
Author identifier: 0000-0001-6418-1822
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://erj.ersjournals.com/content/59/2/2100412
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Respiratory Journal. 59 (2):
APA: Jimenez, David; Rodriguez, Carmen; Leon, Francisco; Jara-Palomares, Luis; Lopez-Reyes, Raquel; Ruiz-Artacho, Pedro; Elias, Teresa; Otero, Remedios; Ga (2022). Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism. European Respiratory Journal, 59(2), -. DOI: 10.1183/13993003.00412-2021
Article's DOI: 10.1183/13993003.00412-2021
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV