Author, as appears in the article.: Steinegger B; Iacopini I; Teixeira AS; Bracci A; Casanova-Ferrer P; Antonioni A; Valdano E
Department: Enginyeria Informàtica i Matemàtiques
URV's Author/s: Steinegger, Benjamin Franz Josef
Keywords: efficacy hiv men msm vaccine Preexposure prophylaxis
Abstract: Epidemic control often requires optimal distribution of available vaccines and prophylactic tools, to protect from infection those susceptible. Well-established theory recommends prioritizing those at the highest risk of exposure. But the risk is hard to estimate, especially for diseases involving stigma and marginalization. We address this conundrum by proving that one should target those at high risk only if the infection-averting efficacy of prevention is above a critical value, which we derive analytically. We apply this to the distribution of pre-exposure prophylaxis (PrEP) of the Human Immunodeficiency Virus (HIV) among men-having-sex-with-men (MSM), a population particularly vulnerable to HIV. PrEP is effective in averting infections, but its global scale-up has been slow, showing the need to revisit distribution strategies, currently risk-based. Using data from MSM communities in 58 countries, we find that non-selective PrEP distribution often outperforms risk-based, showing that a logistically simpler strategy is also more effective. Our theory may help design more feasible and successful prevention.© 2022. The Author(s).
Thematic Areas: Antropologia / arqueologia Astronomia / física Biochemistry, genetics and molecular biology (all) Biochemistry, genetics and molecular biology (miscellaneous) Biodiversidade Biotecnología Chemistry (all) Chemistry (miscellaneous) Ciência da computação Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Engenharias iv Farmacia General biochemistry,genetics and molecular biology General chemistry General medicine General physics and astronomy Geociências Interdisciplinar Matemática / probabilidade e estatística Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Multidisciplinary Multidisciplinary sciences Nutrição Odontología Physics and astronomy (all) Physics and astronomy (miscellaneous) Planejamento urbano e regional / demografia Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: benjamin.steinegger@estudiants.urv.cat
Author identifier: 0000-0002-0723-1536
Record's date: 2024-09-07
Paper version: info:eu-repo/semantics/publishedVersion
Paper original source: Nature Communications. 13 (1): 3028-3028
APA: Steinegger B; Iacopini I; Teixeira AS; Bracci A; Casanova-Ferrer P; Antonioni A; Valdano E (2022). Non-selective distribution of infectious disease prevention may outperform risk-based targeting. Nature Communications, 13(1), 3028-3028. DOI: 10.1038/s41467-022-30639-3
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV