Articles producció científica> Medicina i Cirurgia

Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology

  • Identification data

    Identifier: imarina:9264858
  • Authors:

    Laia Bertran, Ailende Eigbefoh-Addeh, Marta Portillo-Carrasquer, Andrea Barrientos-Riosalido, Jessica Binetti, Carmen Aguilar, Javier Ugarte Chicote, Helena Bartra, Laura Artigas, Mireia Coma,Cristóbal Richart and Teresa Auguet
    Biomedicines
    10.3390/biomedicines10061315
    Biomedicines. 10 (6): 1315-
  • Others:

    Author, as appears in the article.: Laia Bertran, Ailende Eigbefoh-Addeh, Marta Portillo-Carrasquer, Andrea Barrientos-Riosalido, Jessica Binetti, Carmen Aguilar, Javier Ugarte Chicote, Helena Bartra, Laura Artigas, Mireia Coma,Cristóbal Richart and Teresa Auguet
    Department: Medicina i Cirurgia
    URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Binetti, Jessica Angela / Eigbefoh-Addeh Imafidon, Ailende / Richart Jurado, Cristobal Manuel
    Keywords: Systems biology Runx1 Protein-kinase-c Nash Nafld Metabolism systems biology reference database pathway nf-kappa-b nash nafld metabolism insulin-resistance growth-factor gene cell apoptosis alpha expression activation
    Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disease; nevertheless, no definitive diagnostic method exists yet, apart from invasive liver biopsy, and nor is there a specific approved treatment. Runt‐related transcription factor 1 (RUNX1) plays a major role in angiogenesis and inflammation; however, its link with NAFLD is unclear as controversial results have been reported. Thus, the objective of this work was to determine the proteins involved in the molecular mechanisms between RUNX1 and NAFLD, by means of systems biology. First, a mathematical model that simulates NAFLD pathophysiology was generated by analyzing Anax-omics databases and reviewing available scientific literature. Artificial neural networks established NAFLD pathophysiological processes functionally related to RUNX1: hepatic insulin resistance, lipotoxicity, and hepatic injury‐liver fibrosis. Our study indicated that RUNX1 might have a high relationship with hepatic injury‐liver fibrosis, and a medium relationship with lipotoxicity and insulin resistance motives. Additionally, we found five RUNX1‐regulated proteins with a direct in-volvement in NAFLD motives, which were NFκB1, NFκB2, TNF, ADIPOQ, and IL‐6. In conclusion, we suggested a relationship between RUNX1 and NAFLD since RUNX1 seems to regulate NAFLD molecular pathways, posing it as a potential therapeutic target of NAFLD, although more studies in this field are needed.
    Thematic Areas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
    Author's mail: cristobalmanuel.richart@urv.cat ailende.eigbefoh-addeh@urv.cat andrea.barrientos@urv.cat andrea.barrientos@urv.cat jessicaangela.binetti@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
    Author identifier: 0000-0003-0852-6739 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
    Record's date: 2024-07-20
    Link to the original source: https://www.mdpi.com/2227-9059/10/6/1315
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biomedicines. 10 (6): 1315-
    APA: Laia Bertran, Ailende Eigbefoh-Addeh, Marta Portillo-Carrasquer, Andrea Barrientos-Riosalido, Jessica Binetti, Carmen Aguilar, Javier Ugarte Chicote, (2022). Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology. Biomedicines, 10(6), 1315-. DOI: 10.3390/biomedicines10061315
    Article's DOI: 10.3390/biomedicines10061315
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Biochemistry, Genetics and Molecular Biology (Miscellaneous),Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology & Pharmacy
    Systems biology
    Runx1
    Protein-kinase-c
    Nash
    Nafld
    Metabolism
    systems biology
    reference database
    pathway
    nf-kappa-b
    nash
    nafld
    metabolism
    insulin-resistance
    growth-factor
    gene
    cell apoptosis
    alpha expression
    activation
    Pharmacology & pharmacy
    Medicine, research & experimental
    Medicine (miscellaneous)
    General biochemistry,genetics and molecular biology
    Ciencias sociales
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Biochemistry & molecular biology
  • Documents:

  • Cerca a google

    Search to google scholar