Author, as appears in the article.: Companys, Judit; Calderon-Perez, Lorena; Pla-Paga, Laura; Llaurado, Elisabet; Andree Sandoval-Ramirez, Berner; Jose Gosalbes, Maria; Arregui, Ainara; Barandiaran, Maddi; Caimari, Antoni; Maria del Bas, Josep; Arola, Lluis; Valls, Rosa M.; Sola, Rosa; Pedret, Anna;
Department: Medicina i Cirurgia
URV's Author/s: Arola Ferrer, Luis Maria / Calderon Pérez, Lorena / Companys Alemany, Judit / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / PLA PAGA, LAURA / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Type 2 diabetes management Postbiotics Overweight Omega 3 Nitric-oxide Mass Inulin Impact Gut microbiota Fat Cardiometabolic disease Body-weight Blood-pressure Adults Adiposity
Abstract: Purpose To assess the effects of enriched seafood sticks with postbiotic and bioactive compounds on CMD risk factors and the gut microbiota in abdominally obese individuals.Methods Randomized, double-blind, parallel, placebo-controlled trial with abdominally obese individuals. Participants (n= 120) consumed 50 g/day of enriched seafood sticks containing SIAP: (10(10) colony forming units (CFUs) of heat-inactivated B. animalis subsp. lactis CECT8145, 370 mg/day omega 3 and 1.7 g/day inulin), or 50 g/day of placebo seafood sticks for 12 weeks. At 12 weeks, an acute single-dose study of 4 h was performed.Results Sustained SIAP2 consumption significantly decreased the insulin by - 5.25 mg/dL and HOMA-IR (homeostatic Model Assessment of Insulin Resistance) by - 1.33. In women, SIAP2 consumption significantly decreased the pulse pressure (PP) by - 4.69 mmHg Gut microbiota analysis showed a negative association between glycemic parameter reduction and Alistipes finegoldii and Ruminococcaceae, and between PP reduction and Prevotella 9-ASV0283 and Christensenellaceae. In the acute single dose-study 4-h, SIAP2 consumption produced a lower increase in the postprandial circulating triglyceride levels [23.9 (7.03) mg/dL (mean [standard error])] than the observed with placebo [49.0 (9.52)] mg/dL.Conclusion In abdominally obese individuals, enriched seafood sticks induce a potential protection against type 2 diabetes development by the reduction in the insulin and HOMA-IR; and in cardiovascular disease, in women, by the PP reduction. These effects are accompanied by partial changes in the gut microbiota composition. The enriched seafood sticks reduce the atherogenic triglyceride postprandial concentrations. Our results support the use of enriched seafood sticks as a complementary strategy in the management of CMD risk factors.
Thematic Areas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: judit.companys@urv.cat lorena.calderon@urv.cat anna.pedret@urv.cat elisabet.llaurado@urv.cat judit.companys@urv.cat judit.companys@urv.cat lorena.calderon@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-5327-932X 0000-0002-7439-9531 0000-0003-1485-0818 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://link.springer.com/article/10.1007/s00394-022-02904-0
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Journal Of Nutrition. 61 (7): 3597-3611
APA: Companys, Judit; Calderon-Perez, Lorena; Pla-Paga, Laura; Llaurado, Elisabet; Andree Sandoval-Ramirez, Berner; Jose Gosalbes, Maria; Arregui, Ainara; (2022). Effects of enriched seafood sticks (heat-inactivated B. animalis subsp. lactis CECT 8145, inulin, omega-3) on cardiometabolic risk factors and gut microbiota in abdominally obese subjects: randomized controlled trial. European Journal Of Nutrition, 61(7), 3597-3611. DOI: 10.1007/s00394-022-02904-0
Article's DOI: 10.1007/s00394-022-02904-0
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV