Articles producció científica> Bioquímica i Biotecnologia

Impact of New Drugs for Therapeutic Intervention in Alzheimer's Disease

  • Identification data

    Identifier: imarina:9265274
    Authors:
    Olloquequi JEttcheto MCano ASanchez-López ECarrasco MEspinosa TBeas-Zarate CGudiño-Cabrera GUreña-Guerrero MEVerdaguer EFolch JAuladell CCamins A
    Abstract:
    The increases in population ageing and growth are leading to a boosting in the number of people living with dementia, Alzheimer's disease (AD) being the most common cause. In spite of decades of intensive research, no cure for AD has been found yet. However, some treatments that may change disease progression and help control symptoms have been proposed. Beyond the classical hypotheses of AD etiopathogenesis, i.e., amyloid beta peptide (Aβ) accumulation and tau hyperphosphorylation, a trend in attributing a key role to other molecular mechanisms is prompting the study of different therapeutic targets. Hence, drugs designed to modulate inflammation, insulin resistance, synapses, neurogenesis, cardiovascular factors and dysbiosis are shaping a new horizon in AD treatment. Within this frame, an increase in the number of candidate drugs for disease modification treatments is expected, as well as a focus on potential combinatory multidrug strategies.The present review summarizes the latest advances in drugs targeting Aβ and tau as major contributors to AD pathophysiology. In addition, it introduces the most important drugs in clinical studies targeting alternative mechanisms thought to be involved in AD's neurodegenerative process.
  • Others:

    Author, as appears in the article.: Olloquequi J; Ettcheto M; Cano A; Sanchez-López E; Carrasco M; Espinosa T; Beas-Zarate C; Gudiño-Cabrera G; Ureña-Guerrero ME; Verdaguer E; Folch J; Auladell C; Camins A
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Folch Lopez, Jaume
    Keywords: Synapses Novel therapies Nonsteroidal antiinflammatory drugs Neuroinflammation Dementia Clinical studies synaptic loss synapses receptor novel therapies neuropathologic assessment neuroinflammation mild cognitive impairment mast-cells hypothesis clinical studies brain amyloid-beta oligomers
    Abstract: The increases in population ageing and growth are leading to a boosting in the number of people living with dementia, Alzheimer's disease (AD) being the most common cause. In spite of decades of intensive research, no cure for AD has been found yet. However, some treatments that may change disease progression and help control symptoms have been proposed. Beyond the classical hypotheses of AD etiopathogenesis, i.e., amyloid beta peptide (Aβ) accumulation and tau hyperphosphorylation, a trend in attributing a key role to other molecular mechanisms is prompting the study of different therapeutic targets. Hence, drugs designed to modulate inflammation, insulin resistance, synapses, neurogenesis, cardiovascular factors and dysbiosis are shaping a new horizon in AD treatment. Within this frame, an increase in the number of candidate drugs for disease modification treatments is expected, as well as a focus on potential combinatory multidrug strategies.The present review summarizes the latest advances in drugs targeting Aβ and tau as major contributors to AD pathophysiology. In addition, it introduces the most important drugs in clinical studies targeting alternative mechanisms thought to be involved in AD's neurodegenerative process.
    Thematic Areas: Química Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and microbiology (miscellaneous) Immunology and microbiology (all) General immunology and microbiology General biochemistry,genetics and molecular biology Farmacia Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cell biology Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jaume.folch@urv.cat
    Author identifier: 0000-0002-5051-8858
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.imrpress.com/journal/FBL/27/5/10.31083/j.fbl2705146
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers In Bioscience-Landmark. 27 (5): 146-
    APA: Olloquequi J; Ettcheto M; Cano A; Sanchez-López E; Carrasco M; Espinosa T; Beas-Zarate C; Gudiño-Cabrera G; Ureña-Guerrero ME; Verdaguer E; Folch J; A (2022). Impact of New Drugs for Therapeutic Intervention in Alzheimer's Disease. Frontiers In Bioscience-Landmark, 27(5), 146-. DOI: 10.31083/j.fbl2705146
    Article's DOI: 10.31083/j.fbl2705146
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Biochemistry, Genetics and Molecular Biology (Miscellaneous),Cell Biology,Immunology and Microbiology (Miscellaneous),Medicine (Miscellaneous)
    Synapses
    Novel therapies
    Nonsteroidal antiinflammatory drugs
    Neuroinflammation
    Dementia
    Clinical studies
    synaptic loss
    synapses
    receptor
    novel therapies
    neuropathologic assessment
    neuroinflammation
    mild cognitive impairment
    mast-cells
    hypothesis
    clinical studies
    brain
    amyloid-beta oligomers
    Química
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Immunology and microbiology (miscellaneous)
    Immunology and microbiology (all)
    General immunology and microbiology
    General biochemistry,genetics and molecular biology
    Farmacia
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry, genetics and molecular biology (miscellaneous)
    Biochemistry, genetics and molecular biology (all)
    Biochemistry & molecular biology
  • Documents:

  • Cerca a google

    Search to google scholar