Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Emerging nanomaterials for targeting peroxisomes

  • Identification data

    Identifier: imarina:9267359
    Authors:
    Bachhuka, AkashYadav, Tara ChandSantos, AbelMarsal, Lluis FErgun, SueleymanKarnati, Srikanth
    Abstract:
    Peroxisomes are single membrane-bound metabolic organelles whose dysfunction can lead to several metabolic disorders. In addition, they have been associated with the pathology of several diseases such as cancer, autoimmune diseases, diabetes, stroke, etc. In the last few decades, research has been focused on detecting peroxisomes in the physiological environment. However, the detection of these peroxisomes was based on fluorescent probes, which had limited success due to their toxicity, photobleaching, poor selectivity, and spontaneous oxidation. Moreover, research has been focused on mimicking the functionality of peroxisomes by fabricating artificial peroxisomes using synthetic materials, which have been limited due to poor stability and biocompatibility. Therefore, a new class of materials, "nanomaterials" has shown promise in overcoming the limitations underlying traditional techniques by providing better optical properties, stability and biocompatibility. Despite the advancement, the field remains in its infancy. Only a handful of studies have reported nanomaterials such as quantum dots, zeolites, liposomes, dendrimers, and nanoparticles to detect and fabricate peroxisomes. This review will provide a general description of peroxisomes and their role in different metabolic activities. The later part will focus on the challenges and progress related to nanomaterials-based peroxisome detection, fabrication, and delivery. This review will also provide insights into the critical research gaps and advances on different strategies utilized to explore peroxisomes, opening new avenues for future research in this field.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.
  • Others:

    Author, as appears in the article.: Bachhuka, Akash; Yadav, Tara Chand; Santos, Abel; Marsal, Lluis F; Ergun, Sueleyman; Karnati, Srikanth
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Bachhuka, Akash / Marsal Garví, Luis Francisco
    Keywords: Rat-liver peroxisomes Proliferator-activated receptors Ppar-alpha Peroxisomes Nanozymes Nanomaterials Metabolic disorders Intracellular delivery Glutathione-s-transferase Docosahexaenoic acid Carbon nanotubes Beta-oxidation Artificial organelles Arti ficial organelles Antioxidant activity Acid alpha-oxidation
    Abstract: Peroxisomes are single membrane-bound metabolic organelles whose dysfunction can lead to several metabolic disorders. In addition, they have been associated with the pathology of several diseases such as cancer, autoimmune diseases, diabetes, stroke, etc. In the last few decades, research has been focused on detecting peroxisomes in the physiological environment. However, the detection of these peroxisomes was based on fluorescent probes, which had limited success due to their toxicity, photobleaching, poor selectivity, and spontaneous oxidation. Moreover, research has been focused on mimicking the functionality of peroxisomes by fabricating artificial peroxisomes using synthetic materials, which have been limited due to poor stability and biocompatibility. Therefore, a new class of materials, "nanomaterials" has shown promise in overcoming the limitations underlying traditional techniques by providing better optical properties, stability and biocompatibility. Despite the advancement, the field remains in its infancy. Only a handful of studies have reported nanomaterials such as quantum dots, zeolites, liposomes, dendrimers, and nanoparticles to detect and fabricate peroxisomes. This review will provide a general description of peroxisomes and their role in different metabolic activities. The later part will focus on the challenges and progress related to nanomaterials-based peroxisome detection, fabrication, and delivery. This review will also provide insights into the critical research gaps and advances on different strategies utilized to explore peroxisomes, opening new avenues for future research in this field.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Thematic Areas: Mechanical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) General materials science
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: akash.bachhuka@urv.cat lluis.marsal@urv.cat
    Author identifier: 0000-0003-1253-8126 0000-0002-5976-1408
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S2590049822000613
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Materials Today Advances. 15 100265-
    APA: Bachhuka, Akash; Yadav, Tara Chand; Santos, Abel; Marsal, Lluis F; Ergun, Sueleyman; Karnati, Srikanth (2022). Emerging nanomaterials for targeting peroxisomes. Materials Today Advances, 15(), 100265-. DOI: 10.1016/j.mtadv.2022.100265
    Article's DOI: 10.1016/j.mtadv.2022.100265
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Mechanical Engineering
    Rat-liver peroxisomes
    Proliferator-activated receptors
    Ppar-alpha
    Peroxisomes
    Nanozymes
    Nanomaterials
    Metabolic disorders
    Intracellular delivery
    Glutathione-s-transferase
    Docosahexaenoic acid
    Carbon nanotubes
    Beta-oxidation
    Artificial organelles
    Arti ficial organelles
    Antioxidant activity
    Acid alpha-oxidation
    Mechanical engineering
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    General materials science
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