Author, as appears in the article.: Crescenti, Anna; Caimari, Antoni; Maria Alcaide-Hidalgo, Juan; Marine-Casado, Roger; Valls, Rosa M.; Companys, Judit; Salamanca, Patricia; Calderon-Perez, Lorena; Pla-Paga, Laura; Pedret, Anna; Delpino-Rius, Antoni; Herrero, Pol; Samarra, Iris; Arola, Lluis; Sola, Rosa; Del Bas, Josep M.;
Department: Bioquímica i Biotecnologia Medicina i Cirurgia
URV's Author/s: Arola Ferrer, Luis Maria / Companys Alemany, Judit / Pedret Figuerola, Anna / Salamanca González, Patricia / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Urinary-excretion Urinary excretion Pharmacokinetics Orange juice (poly)phenols Naringenin Micronization Metabolites Metabolism Humans Hesperidin diastereoisomers Hesperidin Hesperetin enantiomers Hesperetin Gut microbiota Citrus flavanones Catabolites Bioavailability Absorption
Abstract: Hesperidin is a flavanone abundantly found in citrus fruits for which health beneficial effects have been reported. However, hesperidin shows a low bioavailability among individuals. The aim of this study was to evaluate the effects of the micronization process and 2R- and 2S-hesperidin diastereoisomers ratio on hesperidin bioavailability. In a first phase, thirty healthy individuals consumed 500 mL of orange juice with 345 mg of hesperidin, and the levels of hesperidin metabolites excreted in urine were determined. In the second phase, fifteen individuals with intermediate hesperidin metabolite levels excreted in urine were randomized in a crossover, postprandial and double-blind intervention study. Participants consumed 500 mg of the hesperidin-supplemented Hesperidin epimeric mixture (HEM), the micronized Hesperidin epimeric mixture (MHEM) and micronized 2S-Hesperidin (M2SH) in each study visit with 1 week of washout. Hesperidin metabolites and catabolites were determined in blood and urine obtained at different timepoints over a 24 h period. The bioavailability-relative urinary hesperidin excretion (% of hesperidin ingested)-of M2SH (70 +/- 14%) formed mainly by 2S-diastereoisomer was significantly higher than the bioavailability of the MHEM (55 +/- 15%) and HEM (43 +/- 8.0%), which consisted of a mixture of both hesperidin diastereoisomers. Relative urinary excretion of hesperidin metabolites for MHEM (9.2 +/- 1.6%) was significantly higher compared to the HEM (5.2 +/- 0.81%) and M2SH (3.6 +/- 1.0%). In conclusion, the bioavailability of 2S-hesperidin extract was higher compared to the standard mixture of 2S-/2R-hesperidin extract due to a greater formation of hesperidin catabolites. Furthermore, the micronization process increased hesperidin bioavailability.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: judit.companys@urv.cat anna.pedret@urv.cat patricia.salamanca@estudiants.urv.cat patricia.salamanca@estudiants.urv.cat judit.companys@urv.cat judit.companys@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0003-1485-0818 0000-0002-5327-932X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/12/2481
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (12):
APA: Crescenti, Anna; Caimari, Antoni; Maria Alcaide-Hidalgo, Juan; Marine-Casado, Roger; Valls, Rosa M.; Companys, Judit; Salamanca, Patricia; Calderon-Pe (2022). Hesperidin Bioavailability Is Increased by the Presence of 2S-Diastereoisomer and Micronization-A Randomized, Crossover and Double-Blind Clinical Trial. Nutrients, 14(12), -. DOI: 10.3390/nu14122481
Article's DOI: 10.3390/nu14122481
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV