Articles producció científica> Medicina i Cirurgia

Hesperidin Bioavailability Is Increased by the Presence of 2S-Diastereoisomer and Micronization-A Randomized, Crossover and Double-Blind Clinical Trial

  • Identification data

    Identifier: imarina:9267361
  • Authors:

    Crescenti, Anna
    Caimari, Antoni
    Maria Alcaide-Hidalgo, Juan
    Marine-Casado, Roger
    Valls, Rosa M.
    Companys, Judit
    Salamanca, Patricia
    Calderon-Perez, Lorena
    Pla-Paga, Laura
    Pedret, Anna
    Delpino-Rius, Antoni
    Herrero, Pol
    Samarra, Iris
    Arola, Lluis
    Sola, Rosa
    Del Bas, Josep M.
  • Others:

    Author, as appears in the article.: Crescenti, Anna; Caimari, Antoni; Maria Alcaide-Hidalgo, Juan; Marine-Casado, Roger; Valls, Rosa M.; Companys, Judit; Salamanca, Patricia; Calderon-Perez, Lorena; Pla-Paga, Laura; Pedret, Anna; Delpino-Rius, Antoni; Herrero, Pol; Samarra, Iris; Arola, Lluis; Sola, Rosa; Del Bas, Josep M.;
    Department: Bioquímica i Biotecnologia Medicina i Cirurgia
    URV's Author/s: Arola Ferrer, Luis Maria / Companys Alemany, Judit / Pedret Figuerola, Anna / Salamanca González, Patricia / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
    Keywords: Urinary-excretion Urinary excretion Pharmacokinetics Orange juice (poly)phenols Naringenin Micronization Metabolites Metabolism Humans Hesperidin diastereoisomers Hesperidin Hesperetin enantiomers Hesperetin Gut microbiota Citrus flavanones Catabolites Bioavailability Absorption
    Abstract: Hesperidin is a flavanone abundantly found in citrus fruits for which health beneficial effects have been reported. However, hesperidin shows a low bioavailability among individuals. The aim of this study was to evaluate the effects of the micronization process and 2R- and 2S-hesperidin diastereoisomers ratio on hesperidin bioavailability. In a first phase, thirty healthy individuals consumed 500 mL of orange juice with 345 mg of hesperidin, and the levels of hesperidin metabolites excreted in urine were determined. In the second phase, fifteen individuals with intermediate hesperidin metabolite levels excreted in urine were randomized in a crossover, postprandial and double-blind intervention study. Participants consumed 500 mg of the hesperidin-supplemented Hesperidin epimeric mixture (HEM), the micronized Hesperidin epimeric mixture (MHEM) and micronized 2S-Hesperidin (M2SH) in each study visit with 1 week of washout. Hesperidin metabolites and catabolites were determined in blood and urine obtained at different timepoints over a 24 h period. The bioavailability-relative urinary hesperidin excretion (% of hesperidin ingested)-of M2SH (70 +/- 14%) formed mainly by 2S-diastereoisomer was significantly higher than the bioavailability of the MHEM (55 +/- 15%) and HEM (43 +/- 8.0%), which consisted of a mixture of both hesperidin diastereoisomers. Relative urinary excretion of hesperidin metabolites for MHEM (9.2 +/- 1.6%) was significantly higher compared to the HEM (5.2 +/- 0.81%) and M2SH (3.6 +/- 1.0%). In conclusion, the bioavailability of 2S-hesperidin extract was higher compared to the standard mixture of 2S-/2R-hesperidin extract due to a greater formation of hesperidin catabolites. Furthermore, the micronization process increased hesperidin bioavailability.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: judit.companys@urv.cat anna.pedret@urv.cat patricia.salamanca@estudiants.urv.cat patricia.salamanca@estudiants.urv.cat judit.companys@urv.cat judit.companys@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
    Author identifier: 0000-0003-1485-0818 0000-0002-5327-932X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/14/12/2481
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 14 (12):
    APA: Crescenti, Anna; Caimari, Antoni; Maria Alcaide-Hidalgo, Juan; Marine-Casado, Roger; Valls, Rosa M.; Companys, Judit; Salamanca, Patricia; Calderon-Pe (2022). Hesperidin Bioavailability Is Increased by the Presence of 2S-Diastereoisomer and Micronization-A Randomized, Crossover and Double-Blind Clinical Trial. Nutrients, 14(12), -. DOI: 10.3390/nu14122481
    Article's DOI: 10.3390/nu14122481
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Urinary-excretion
    Urinary excretion
    Pharmacokinetics
    Orange juice (poly)phenols
    Naringenin
    Micronization
    Metabolites
    Metabolism
    Humans
    Hesperidin diastereoisomers
    Hesperidin
    Hesperetin enantiomers
    Hesperetin
    Gut microbiota
    Citrus flavanones
    Catabolites
    Bioavailability
    Absorption
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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