Articles producció científica> Química Analítica i Química Orgànica

Development of sol-gel silica-based mixed-mode zwitterionic sorbents for determining drugs in environmental water samples

  • Identification data

    Identifier: imarina:9267430
  • Authors:

    Moral A
    Borrull F
    Furton KG
    Kabir A
    Fontanals N
    Marcé RM
  • Others:

    Author, as appears in the article.: Moral A; Borrull F; Furton KG; Kabir A; Fontanals N; Marcé RM
    Department: Química Analítica i Química Orgànica
    URV's Author/s: Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria
    Keywords: Solid-phase extraction Silica sorbents Mixed-mode zwitterionic sorbents Environmental samples Basic compounds
    Abstract: Four novel mixed-mode zwitterionic silica-based functionalized with strong moieties sorbents were synthesized and evaluated through solid-phase extraction (SPE) to determine acidic and basic drugs in environmental water samples. All sorbents had the same functionalization: quaternary amine and sulfonic groups and C18 chains so that hydrophobic and strong cationic exchange (SCX) and strong anionic exchange (SAX) interactions could be exploited, in addition, two of them had carbon microparticles embedded. All sorbents retained both acidic and basic compounds in the preliminary assays but only the basic compounds were retained selectively through ionic exchange interactions when a clean-up step was introduced. The SPE method was therefore optimized to promote the selective retention of the basic compounds, initially with the two best-performing sorbents. After optimization of the SPE protocol, these sorbents were evaluated for the analysis of environmental water samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method with the best-performing sorbent was then validated with 100 mL of river samples and 50 mL of effluent wastewater samples in terms of apparent recoveries (%Rapp) spiking samples at 50 ng/L (river) and 200 ng/L (river and effluent), matrix effect, linear range, method quantification and detection limits, repeatability, and reproducibility. It should be highlighted that %Rapp ranged from 40 to 85% and matrix effects ranged from -17 to -4% for spiked river samples. When the method was applied to river and effluent wastewater samples, most compounds were found in the range from 24 to 1233 ng/L with detection limits from 1 to 5 ng/L.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Organic chemistry Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Analytical chemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nuria.fontanals@urv.cat nuria.fontanals@urv.cat rosamaria.marce@urv.cat
    Author identifier: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0002-5667-2899
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0021967322004307
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Chromatography a. 1676 463237-
    APA: Moral A; Borrull F; Furton KG; Kabir A; Fontanals N; Marcé RM (2022). Development of sol-gel silica-based mixed-mode zwitterionic sorbents for determining drugs in environmental water samples. Journal Of Chromatography a, 1676(), 463237-. DOI: 10.1016/j.chroma.2022.463237
    Article's DOI: 10.1016/j.chroma.2022.463237
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Analytical Chemistry,Biochemical Research Methods,Biochemistry,Chemistry, Analytical,Medicine (Miscellaneous),Organic Chemistry
    Solid-phase extraction
    Silica sorbents
    Mixed-mode zwitterionic sorbents
    Environmental samples
    Basic compounds
    Zootecnia / recursos pesqueiros
    Química
    Organic chemistry
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    Farmacia
    Engenharias ii
    Engenharias i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, analytical
    Biotecnología
    Biodiversidade
    Biochemistry
    Biochemical research methods
    Analytical chemistry
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