Articles producció científica> Medicina i Cirurgia

Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19

  • Identification data

    Identifier: imarina:9268338
  • Authors:

    Gabaldó, X
    Juanpere, M
    Castañé, H
    Rodríguez-Tomàs, E
    López-Azcona, AF
    Baiges-Gaya, G
    Castro, L
    Valverde-Díaz, E
    Muñoz-Blázquez, A
    Giménez-Cuenca, L
    Felipo-Balada, L
    Ballester, F
    Pujol, I
    Simó, JM
    Castro, A
    Iftimie, S
    Camps, J
    Joven, J
  • Others:

    Author, as appears in the article.: Gabaldó, X; Juanpere, M; Castañé, H; Rodríguez-Tomàs, E; López-Azcona, AF; Baiges-Gaya, G; Castro, L; Valverde-Díaz, E; Muñoz-Blázquez, A; Giménez-Cuenca, L; Felipo-Balada, L; Ballester, F; Pujol, I; Simó, JM; Castro, A; Iftimie, S; Camps, J; Joven, J
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    URV's Author/s: Alkhoury, Nadine / Baiges Gaya, Gerard / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Castro Salomó, Antoni / Iftimie Iftimie, Simona Mihaela / Joven Maried, Jorge / Pujol Bajador, Isabel / Rodriguez Tomas, Elisabet
    Keywords: Sars-cov-2 Paraoxonase-1 Covid-19 Biomarkers sars-cov-2 paraoxonase-1 covid-19
    Abstract: The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as a screening test in patients with different severity levels of COVID-19 infection. We included 615 COVID-19-positive patients who were classified as asymptomatic, mildly symptomatic, severely symptomatic, or fatally symptomatic. Results were compared with 50 healthy volunteers, 330 patients with cancer, and 343 with morbid obesity. Results showed PON1 activity greatly decreased in COVID-19 compared to healthy volunteers; a receiver operating characteristics plot showed a high diagnostic accuracy. The degree of COVID-19 severity did not influence PON1 levels. Our results indicated that PON1 determination was efficient for disease diagnosis, but not for prognosis. Furthermore, patients with obesity or cancer presented alterations similar to those of COVID-19 patients. As such, elevated levels of PON1 indicate the absence of COVID-19, but low levels may be present in various other chronic diseases. The assay is fast and inexpensive. We suggest that PON1 measurement could be used as an initial, high cut-off point screening method, while lower values should be confirmed with the more expensive nucleic acid amplification test.
    Thematic Areas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: simonamihaela.iftime@urv.cat jorge.camps@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat helena.castane@estudiants.urv.cat gerard.baiges@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat jorge.joven@urv.cat antoni.castro@urv.cat isabel.pujol@urv.cat
    Author identifier: 0000-0003-0714-8414 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-5441-6333
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2218-273X/12/7/879
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biomolecules. 12 (7): 879-
    APA: Gabaldó, X; Juanpere, M; Castañé, H; Rodríguez-Tomàs, E; López-Azcona, AF; Baiges-Gaya, G; Castro, L; Valverde-Díaz, E; Muñoz-Blázquez, A; Giménez-Cue (2022). Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19. Biomolecules, 12(7), 879-. DOI: 10.3390/biom12070879
    Article's DOI: 10.3390/biom12070879
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Molecular Biology
    Sars-cov-2
    Paraoxonase-1
    Covid-19
    Biomarkers
    sars-cov-2
    paraoxonase-1
    covid-19
    Química
    Molecular biology
    Materiais
    General medicine
    Farmacia
    Ensino
    Biochemistry & molecular biology
    Biochemistry
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