Articles producció científica> Medicina i Cirurgia

New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease

  • Identification data

    Identifier: imarina:9271504
    Authors:
    Bertran, LaiaJorba-Martin, RosaBarrientos-Riosalido, AndreaPortillo-Carrasquer, MartaAguilar, CarmenRiesco, DavidMartinez, SalomeVives, MargaritaSabench, FatimaDel Castillo, DanielRichart, CristobalAuguet, Teresa
    Abstract:
    Olfactomedins (OLFMs) are a family of glycoproteins that play a relevant role in embryonic development and in some pathological processes. Although OLFM2 is involved in the regulation of the energy metabolism and OLFM4 is an important player in inflammation, innate immunity and cancer, the role of OLFMs in NAFLD-related intestinal dysbiosis remains unknown. In this study, we analysed the hepatic mRNA expression of OLFM2 and the jejunal expression of OLFM4 in a well-established cohort of women with morbid obesity (MO), classified according to their hepatic histology into normal liver (n = 27), simple steatosis (n = 26) and nonalcoholic steatohepatitis (NASH, n = 16). Our results showed that OLFM2 hepatic mRNA was higher in NASH, in advanced degrees of steatosis and in the presence of lobular inflammation. Additionally, we obtained positive correlations between hepatic OLFM2 and glucose, cholesterol, trimethylamine N-oxide and deoxycholic acid levels and hepatic fatty acid synthase, and negative associations with weight and jejunal Toll-like receptors (TLR4) and TLR5 expression. Regarding jejunal OLFM4, we observed positive correlations with circulating interleukin (IL)-8, IL-10, IL-17 and jejunal TLR9. In conclusion, OLFM2 in the liver seems to play a relevant role in NAFLD progression, while OLFM4 in the jejunum could be involved in gut dysbiosis-related inflammatory events.
  • Others:

    Author, as appears in the article.: Bertran, Laia; Jorba-Martin, Rosa; Barrientos-Riosalido, Andrea; Portillo-Carrasquer, Marta; Aguilar, Carmen; Riesco, David; Martinez, Salome; Vives, Margarita; Sabench, Fatima; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa
    Department: Medicina i Cirurgia
    URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Del Castillo Déjardin, Daniel / Jorba Martin, Rosa Maria / Martínez González, María Salomé / Martinez Lluis, Sergio / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima / VIVES
    Keywords: Steatohepatitis Rna, messenger Olfm4 protein, human Olfm2 protein, human Olfactomedin Obesity Nonalcoholic fatty liver disease Non-alcoholic fatty liver disease Mice Metabolic syndrome Liver Intestinal microbiota Interleukin-10 Innate immunity Inflammation Humans Hgc-1 Gut‐liver axis Gut-liver axis Granulocyte colony-stimulating factor Glycoproteins Female Extracellular matrix proteins Expression Dysbiosis Differentiation
    Abstract: Olfactomedins (OLFMs) are a family of glycoproteins that play a relevant role in embryonic development and in some pathological processes. Although OLFM2 is involved in the regulation of the energy metabolism and OLFM4 is an important player in inflammation, innate immunity and cancer, the role of OLFMs in NAFLD-related intestinal dysbiosis remains unknown. In this study, we analysed the hepatic mRNA expression of OLFM2 and the jejunal expression of OLFM4 in a well-established cohort of women with morbid obesity (MO), classified according to their hepatic histology into normal liver (n = 27), simple steatosis (n = 26) and nonalcoholic steatohepatitis (NASH, n = 16). Our results showed that OLFM2 hepatic mRNA was higher in NASH, in advanced degrees of steatosis and in the presence of lobular inflammation. Additionally, we obtained positive correlations between hepatic OLFM2 and glucose, cholesterol, trimethylamine N-oxide and deoxycholic acid levels and hepatic fatty acid synthase, and negative associations with weight and jejunal Toll-like receptors (TLR4) and TLR5 expression. Regarding jejunal OLFM4, we observed positive correlations with circulating interleukin (IL)-8, IL-10, IL-17 and jejunal TLR9. In conclusion, OLFM2 in the liver seems to play a relevant role in NAFLD progression, while OLFM4 in the jejunum could be involved in gut dysbiosis-related inflammatory events.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: andrea.barrientos@urv.cat andrea.barrientos@urv.cat davidgerardo.riesco@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat rosamaria.jorba@urv.cat sergio.martinezl@urv.cat
    Author identifier: 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428 0000-0003-3307-4340 0000-0002-3941-5348
    Record's date: 2024-09-28
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1422-0067/23/13/7442/htm
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Molecular Sciences. 23 (13): 7442-
    APA: Bertran, Laia; Jorba-Martin, Rosa; Barrientos-Riosalido, Andrea; Portillo-Carrasquer, Marta; Aguilar, Carmen; Riesco, David; Martinez, Salome; Vives, (2022). New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease. International Journal Of Molecular Sciences, 23(13), 7442-. DOI: 10.3390/ijms23137442
    Article's DOI: 10.3390/ijms23137442
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Steatohepatitis
    Rna, messenger
    Olfm4 protein, human
    Olfm2 protein, human
    Olfactomedin
    Obesity
    Nonalcoholic fatty liver disease
    Non-alcoholic fatty liver disease
    Mice
    Metabolic syndrome
    Liver
    Intestinal microbiota
    Interleukin-10
    Innate immunity
    Inflammation
    Humans
    Hgc-1
    Gut‐liver axis
    Gut-liver axis
    Granulocyte colony-stimulating factor
    Glycoproteins
    Female
    Extracellular matrix proteins
    Expression
    Dysbiosis
    Differentiation
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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