Articles producció científica> Bioquímica i Biotecnologia

A double-blinded, randomized, parallel intervention to evaluate biomarker-based nutrition plans for weight loss: The PREVENTOMICS study

  • Identification data

    Identifier: imarina:9280139
    Handle: https://hdl.handle.net/20.500.11797/imarina9280139
    Authors:
    Aldubayan, Mona APigsborg, KristinaGormsen, Sophia M OSerra, FranciscaPalou, MarionaGalmes, SebastiaPalou-March, AndreuFavari, ClaudiaWetzels, MartCalleja, AlbertoRodriguez Gomez, Miguel AngelGuirro Castellnou, MariaCaimari, AntoniGalofre, MarSunol, DavidEscote, XavierMaria Alcaide-Hidalgo, Juandel Bas, Josep MGutierrez, BiotzaKrarup, ThureHjorth, Mads FMagkos, Faidon
    Abstract:
    Background & aims: Growing evidence suggests that biomarker-guided dietary interventions can optimize response to treatment. In this study, we evaluated the efficacy of the PREVENTOMCIS platform—which uses metabolomic and genetic information to classify individuals into different ‘metabolic clusters’ and create personalized dietary plans—for improving health outcomes in subjects with overweight or obesity. Methods: A 10-week parallel, double-blinded, randomized intervention was conducted in 100 adults (82 completers) aged 18–65 years, with body mass index ≥27 but <40 kg/m2, who were allocated into either a personalized diet group (n = 49) or a control diet group (n = 51). About 60% of all food was provided free-of-charge. No specific instruction to restrict energy intake was given. The primary outcome was change in fat mass from baseline, evaluated by dual energy X-ray absorptiometry. Other endpoints included body weight, waist circumference, lipid profile, glucose homeostasis markers, inflammatory markers, blood pressure, physical activity, stress and eating behavior. Results: There were significant main effects of time (P < 0.01), but no group main effects, or time-by-group interactions, for the change in fat mass (personalized: −2.1 [95% CI -2.9, −1.4] kg; control: −2.0 [95% CI -2.7, −1.3] kg) and body weight (personalized: −3.1 [95% CI -4.1, −2.1] kg; control: −3.3 [95% CI −4.2, −2.4] kg). The difference between groups in fat mass change was −0.1 kg (95% CI −1.2, 0.9 kg, P = 0.77). Both diets resulted in significant improvements in insulin resistance and lipid profile, but there were no significant differences between groups. Conclusion: Personalized dietary plans did not result in greater benefits over a generic, but generally healthy diet, in this 10-week clinical

  • Others:

    Author, as appears in the article.: Aldubayan, Mona A; Pigsborg, Kristina; Gormsen, Sophia M O; Serra, Francisca; Palou, Mariona; Galmes, Sebastia; Palou-March, Andreu; Favari, Claudia; Wetzels, Mart; Calleja, Alberto; Rodriguez Gomez, Miguel Angel; Guirro Castellnou, Maria; Caimari, Antoni; Galofre, Mar; Sunol, David; Escote, Xavier; Maria Alcaide-Hidalgo, Juan; del Bas, Josep M; Gutierrez, Biotza; Krarup, Thure; Hjorth, Mads F; Magkos, Faidon
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Del Bas Prior, José María / Escote Miro, Xavier
    Keywords: Weight management Precision nutrition Personalized nutrition Obesity Nutrigenetics Metabolomics Health-biomarkers weight management values precision nutrition overweight obesity nutrigenetics metabolomics insulin health-biomarkers dietary restraint controlled-trial body-weight association adults
    Abstract: Background & aims: Growing evidence suggests that biomarker-guided dietary interventions can optimize response to treatment. In this study, we evaluated the efficacy of the PREVENTOMCIS platform—which uses metabolomic and genetic information to classify individuals into different ‘metabolic clusters’ and create personalized dietary plans—for improving health outcomes in subjects with overweight or obesity. Methods: A 10-week parallel, double-blinded, randomized intervention was conducted in 100 adults (82 completers) aged 18–65 years, with body mass index ≥27 but <40 kg/m2, who were allocated into either a personalized diet group (n = 49) or a control diet group (n = 51). About 60% of all food was provided free-of-charge. No specific instruction to restrict energy intake was given. The primary outcome was change in fat mass from baseline, evaluated by dual energy X-ray absorptiometry. Other endpoints included body weight, waist circumference, lipid profile, glucose homeostasis markers, inflammatory markers, blood pressure, physical activity, stress and eating behavior. Results: There were significant main effects of time (P < 0.01), but no group main effects, or time-by-group interactions, for the change in fat mass (personalized: −2.1 [95% CI -2.9, −1.4] kg; control: −2.0 [95% CI -2.7, −1.3] kg) and body weight (personalized: −3.1 [95% CI -4.1, −2.1] kg; control: −3.3 [95% CI −4.2, −2.4] kg). The difference between groups in fat mass change was −0.1 kg (95% CI −1.2, 0.9 kg, P = 0.77). Both diets resulted in significant improvements in insulin resistance and lipid profile, but there were no significant differences between groups. Conclusion: Personalized dietary plans did not result in greater benefits over a generic, but generally healthy diet, in this 10-week clinical trial. Further studies are required to establish the soundness of different precision nutrition approaches, and translate this science into clinically relevant dietary advice to reduce the burden of obesity and its comorbidities. Clinical trial registry: ClinicalTrials.gov registry (NCT04590989).
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: josepm.delbas@urv.cat xavier.escote@urv.cat
    Author identifier: 0000-0003-1172-3995
    Record's date: 2025-03-15
    Paper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: Clinical Nutrition. 41 (8): 1834-1844
    APA: Aldubayan, Mona A; Pigsborg, Kristina; Gormsen, Sophia M O; Serra, Francisca; Palou, Mariona; Galmes, Sebastia; Palou-March, Andreu; Favari, Claudia; (2022). A double-blinded, randomized, parallel intervention to evaluate biomarker-based nutrition plans for weight loss: The PREVENTOMICS study. Clinical Nutrition, 41(8), 1834-1844. DOI: 10.1016/j.clnu.2022.06.032
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications

  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Weight management
    Precision nutrition
    Personalized nutrition
    Obesity
    Nutrigenetics
    Metabolomics
    Health-biomarkers
    weight management
    values
    precision nutrition
    overweight
    obesity
    nutrigenetics
    metabolomics
    insulin
    health-biomarkers
    dietary restraint
    controlled-trial
    body-weight
    association
    adults
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología

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