Author, as appears in the article.: Martínez-Urbistondo D; San Cristóbal RS; Villares P; Martínez-González MÁ; Babio N; Corella D; del Val JL; Ordovás JM; Alonso-Gómez ÁM; W?rnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Lapetra J; Serra-Majem JL; Bueno-Cavanillas A; Tur JA; Marcos A; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Ros E; Bullón Vela MV; Palau A; Masagué M; Abete I; Moreno-Rodríguez A; Candela-García I; Konieczna J; García-Ríos A; Juárez OL; Martín P; Goday A; Zulet MÁ; Vaquero-Luna J; Orea MdCS; Megías I; Baltasar E; Martínez JA; Daimiel L

Department: Bioquímica i Biotecnologia

URV's Author/s: Babio Sánchez, Nancy Elvira / Martín Lujan, Francisco Manuel / Megías Rangil, Isabel Clara

Keywords: Quality-of-life Physical activity Nafld Metabolic syndrome Mediterranean diet Hrqol physical activity metabolic syndrome mediterranean diet hrqol

Abstract: Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Results: Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).

Thematic Areas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: paco.martin@urv.cat isabel.megias@urv.cat nancy.babio@urv.cat

Author identifier: 0000-0003-0359-3588 0000-0003-3527-5277

Record's date: 2023-05-21

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.frontiersin.org/articles/10.3389/fendo.2022.868795/full

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Frontiers In Endocrinology. 13

APA: Martínez-Urbistondo D; San Cristóbal RS; Villares P; Martínez-González MÁ; Babio N; Corella D; del Val JL; Ordovás JM; Alonso-Gómez ÁM; W?rnberg J; Vi (2022). Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. Frontiers In Endocrinology, 13(), -. DOI: 10.3389/fendo.2022.868795

Article's DOI: 10.3389/fendo.2022.868795

Entity: Universitat Rovira i Virgili

Journal publication year: 2022

Publication Type: Journal Publications