Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort

Identifier:  imarina:9280141

Handle: https://hdl.handle.net/20.500.11797/imarina9280141

Authors:  Martinez-Urbistondo, Diego; San Cristobal, RodrigoSan; Villares, Paula; Martinez-Gonzalez, Miguel Angel; Babio, Nancy; Corella, Dolores; del Val, Jose Luis; Ordovas, Jose M; Alonso-Gomez, Angel M; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, J Luis; Bueno-Cavanillas, Aurora; Tur, Josep A; Marcos, Alba; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Ros, Emilio; Vela, Maria Vanessa Bullon; Palau, Antoni; Masague, Marta; Abete, Itziar; Moreno-Rodriguez, Anai; Candela-Garcia, Inma; Konieczna, Jadwiga; Garcia-Rios, Antonio; Juarez, Oscar Lecea; Martin, Paco; Goday, Albert; Zulet, M Angeles; Vaquero-Luna, Jessica; Orea, Maria del Carmen Sayon; Megias, Isabel; Baltasar, Enric; Martinez, J Alfredo; Daimiel, Lidia

Abstract:
Objective: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). Methods: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. Results: Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. Conclusion: The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870).