Author, as appears in the article.: Marhuenda-Munoz, Maria; Dominguez-Lopez, Ines; Laveriano-Santos, Emily P.; Parilli-Moser, Isabella; Razquin, Cristina; Ruiz-Canela, Miguel; Basterra-Gortari, Francisco Javier; Corella, Dolores; Salas-Salvado, Jordi; Fito, Montserrat; Lapetra, Jose; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Gomez-Gracia, Enrique; Ros, Emilio; Estruch, Ramon; Lamuela-Raventos, Rosa M.;
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Urinary microbial phenolic metabolites Total polyphenols Quantification Predimed study Phytochemicals Olive Mediterranean diet Mass spectrometry Liquid chromatography Health Cardiovascular Blood-pressure Bioactive compounds Anthocyanins Acid
Abstract: The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3921/11/8/1540
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antioxidants. 11 (8):
APA: Marhuenda-Munoz, Maria; Dominguez-Lopez, Ines; Laveriano-Santos, Emily P.; Parilli-Moser, Isabella; Razquin, Cristina; Ruiz-Canela, Miguel; Basterra-G (2022). One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study. Antioxidants, 11(8), -. DOI: 10.3390/antiox11081540
Article's DOI: 10.3390/antiox11081540
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV