Author, as appears in the article.: Llop D; Ibarretxe D; Plana N; Rosales R; Taverner D; Masana L; Vallvé JC; Paredes S
Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
URV's Author/s: Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / PAREDES EGEA, SERGI / Plana Gil, Núria / ROSALES RIBAS, ROSER / Vallvé Torrente, Joan Carles
Keywords: Rheumatoid arthritis Ra Micrornas Intima-media thickness Epigenetics Biomarker Atherosclerosis risk prediction mortality micrornas events epigenetics biomarker atherosclerosis altered expression
Abstract: Patients with rheumatoid arthritis (RA) present increased risk of cardiovascular (CV) disease compared with the general population. Moreover, CV risk factors that have causal relationship with atherosclerosis do not seem to fully explain the accelerated process that they exhibit. We evaluated the association of a 10 microRNAs panel with surrogate markers of subclinical arteriosclerosis (carotid intima media thickness (cIMT), carotid plaque presence (cPP), pulse wave velocity (PWV) and distensibility) in a cohort of RA patients.199 patients with RA were included. Surrogate markers of arteriosclerosis were measured with My Lab 60 X-Vision sonographer. MicroRNAs were extracted from plasma and quantified with qPCR. Multivariate models and classification methods were performed.Multivariate models showed that microRNAs-24 (β = 15.48), 125a (β = 9.93), 132 (β = 11.52), 146 (β = 15.12), 191 (β = 13.25) and 223 (β = 13.30) were associated with cIMT globally. MicroRNA-24 (OR = 0.41), 146 (OR = 0.36) and Let7a (OR = 0.23) were associated with cPP in men. Including the microRNAs in a PLS-DA model properly classified men with and without cPP. MicroRNA-96 (β = -0.28) was associated with PWV in male patients. Finally, several miRNAs were also associated with cIMT, cPP and arterial stiffness in the high DAS28 group and in the earlier tertile groups of disease duration.Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA.© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Thematic Areas: Saúde coletiva Rheumatology Pharmacology (medical) Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: daiana.ibarretxe@urv.cat luis.masana@urv.cat didac.llop@urv.cat jc.vallve@urv.cat didac.llop@urv.cat jc.vallve@urv.cat
Author identifier: 0000-0002-0789-4954
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Rheumatology. 62 (4): keac483-keac483
APA: Llop D; Ibarretxe D; Plana N; Rosales R; Taverner D; Masana L; Vallvé JC; Paredes S (2023). A panel of plasma microRNAs improves the assessment of surrogate markers of cardiovascular disease in rheumatoid arthritis patients. Rheumatology, 62(4), keac483-keac483. DOI: 10.1093/rheumatology/keac483
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV