Articles producció científica> Medicina i Cirurgia

A panel of plasma microRNAs improves the assessment of surrogate markers of cardiovascular disease in rheumatoid arthritis patients

  • Identification data

    Identifier: imarina:9280987
  • Authors:

    Llop D
    Ibarretxe D
    Plana N
    Rosales R
    Taverner D
    Masana L
    Vallvé JC
    Paredes S
  • Others:

    Author, as appears in the article.: Llop D; Ibarretxe D; Plana N; Rosales R; Taverner D; Masana L; Vallvé JC; Paredes S
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / PAREDES EGEA, SERGI / Plana Gil, Núria / ROSALES RIBAS, ROSER / Vallvé Torrente, Joan Carles
    Keywords: Rheumatoid arthritis Ra Micrornas Intima-media thickness Epigenetics Biomarker Atherosclerosis risk prediction mortality micrornas events epigenetics biomarker atherosclerosis altered expression
    Abstract: Patients with rheumatoid arthritis (RA) present increased risk of cardiovascular (CV) disease compared with the general population. Moreover, CV risk factors that have causal relationship with atherosclerosis do not seem to fully explain the accelerated process that they exhibit. We evaluated the association of a 10 microRNAs panel with surrogate markers of subclinical arteriosclerosis (carotid intima media thickness (cIMT), carotid plaque presence (cPP), pulse wave velocity (PWV) and distensibility) in a cohort of RA patients.199 patients with RA were included. Surrogate markers of arteriosclerosis were measured with My Lab 60 X-Vision sonographer. MicroRNAs were extracted from plasma and quantified with qPCR. Multivariate models and classification methods were performed.Multivariate models showed that microRNAs-24 (β  =  15.48), 125a (β  =  9.93), 132 (β  =  11.52), 146 (β  =  15.12), 191 (β  =  13.25) and 223 (β  =  13.30) were associated with cIMT globally. MicroRNA-24 (OR = 0.41), 146 (OR = 0.36) and Let7a (OR = 0.23) were associated with cPP in men. Including the microRNAs in a PLS-DA model properly classified men with and without cPP. MicroRNA-96 (β = -0.28) was associated with PWV in male patients. Finally, several miRNAs were also associated with cIMT, cPP and arterial stiffness in the high DAS28 group and in the earlier tertile groups of disease duration.Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA.© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.
    Thematic Areas: Saúde coletiva Rheumatology Pharmacology (medical) Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: daiana.ibarretxe@urv.cat jc.vallve@urv.cat didac.llop@urv.cat luis.masana@urv.cat jc.vallve@urv.cat didac.llop@urv.cat
    Author identifier: 0000-0002-0789-4954
    Record's date: 2024-01-16
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://academic.oup.com/rheumatology/advance-article-abstract/doi/10.1093/rheumatology/keac483/6682824?redirectedFrom=fulltext
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Rheumatology. 62 (4): keac483-keac483
    APA: Llop D; Ibarretxe D; Plana N; Rosales R; Taverner D; Masana L; Vallvé JC; Paredes S (2023). A panel of plasma microRNAs improves the assessment of surrogate markers of cardiovascular disease in rheumatoid arthritis patients. Rheumatology, 62(4), keac483-keac483. DOI: 10.1093/rheumatology/keac483
    Article's DOI: 10.1093/rheumatology/keac483
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Pharmacology (Medical),Rheumatology
    Rheumatoid arthritis
    Ra
    Micrornas
    Intima-media thickness
    Epigenetics
    Biomarker
    Atherosclerosis
    risk
    prediction
    mortality
    micrornas
    events
    epigenetics
    biomarker
    atherosclerosis
    altered expression
    Saúde coletiva
    Rheumatology
    Pharmacology (medical)
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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