Articles producció científica> Medicina i Cirurgia

Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes

  • Identification data

    Identifier: imarina:9281564
  • Authors:

    Barrot, J
    Real, J
    Vlacho, B
    Romero-Aroca, P
    Simo, R
    Mauricio, D
    Mata-Cases, M
    Castelblanco, E
    Mundet-Tuduri, X
    Franch-Nadal, J
    Frontiers Of Medicine
    10.3389/fmed.2022.945245
    Frontiers Of Medicine. 9
  • Others:

    Author, as appears in the article.: Barrot, J; Real, J; Vlacho, B; Romero-Aroca, P; Simo, R; Mauricio, D; Mata-Cases, M; Castelblanco, E; Mundet-Tuduri, X; Franch-Nadal, J
    Department: Medicina i Cirurgia
    URV's Author/s: Romero Aroca, Pedro
    Keywords: Stroke Risk-factor Real word data analyses Primary healthcare Prevalence Mortality Mellitus Macrovascular complication Heart-disease Epidemiology Diabetic retinopathy Atherosclerosis Association
    Abstract: This study aimed to evaluate the predictive value of diabetic retinopathy (DR) and its stages with the incidence of major cardiovascular events and all-cause mortality in type 2 diabetes mellitus (T2DM) persons in our large primary healthcare database from Catalonia (Spain). A retrospective cohort study with pseudo-anonymized routinely collected health data from SIDIAP was conducted from 2008 to 2016. We calculated incidence rates of major cardiovascular events [coronary heart disease (CHD), stroke, or both-macrovascular events] and all-cause mortality for subjects with and without DR and for different stages of DR. The proportional hazards regression analysis was done to assess the probability of occurrence between DR and the study events. About 22,402 T2DM subjects with DR were identified in the database and 196,983 subjects without DR. During the follow-up period among the subjects with DR, we observed the highest incidence of all-cause mortally. In the second place were the macrovascular events among the subjects with DR. In the multivariable analysis, fully adjusted for DR, sex, age, body mass index (BMI), tobacco, duration of T2DM, an antiplatelet or antihypertensive drug, and HbA1c, we observed that subjects with any stage of DR had higher risks for all of the study events, except for stroke. We observed the highest probability of all-cause death events (adjusted hazard ratios, AHRs: 1.34, 95% CI: 1.28; 1.41). In conclusion, our results show that DR is related to CHD, macrovascular events, and all-cause mortality among persons with T2DM.
    Thematic Areas: Oncology Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii General medicine Farmacia Ciências biológicas i Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: pedro.romero@urv.cat
    Author identifier: 0000-0002-7061-8987
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fmed.2022.945245/full
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers Of Medicine. 9
    APA: Barrot, J; Real, J; Vlacho, B; Romero-Aroca, P; Simo, R; Mauricio, D; Mata-Cases, M; Castelblanco, E; Mundet-Tuduri, X; Franch-Nadal, J (2022). Diabetic retinopathy as a predictor of cardiovascular morbidity and mortality in subjects with type 2 diabetes. Frontiers Of Medicine, 9(), -. DOI: 10.3389/fmed.2022.945245
    Article's DOI: 10.3389/fmed.2022.945245
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental,Oncology
    Stroke
    Risk-factor
    Real word data analyses
    Primary healthcare
    Prevalence
    Mortality
    Mellitus
    Macrovascular complication
    Heart-disease
    Epidemiology
    Diabetic retinopathy
    Atherosclerosis
    Association
    Oncology
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina ii
    General medicine
    Farmacia
    Ciências biológicas i
    Biodiversidade
  • Documents:

  • Cerca a google

    Search to google scholar