Articles producció científica> Medicina i Cirurgia

Antioxidant-rich foods, antioxidant supplements, and sarcopenia in old-young adults ≥55 years old: A systematic review and meta-analysis of observational studies and randomized controlled trials

  • Identification data

    Identifier: imarina:9281742
  • Authors:

    Besora-Moreno M
    Llauradó E
    Valls RM
    Tarro L
    Pedret A
    Solà R
  • Others:

    Author, as appears in the article.: Besora-Moreno M; Llauradó E; Valls RM; Tarro L; Pedret A; Solà R
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    URV's Author/s: Besora Moreno, Maria de la Serra / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria / Tarro Sánchez, Lucía
    Keywords: Sarcopenia Physical function Older adults Muscle strength Muscle mass Healthy elderly-women Antioxidants vitamin-e skeletal-muscle sarcopenia physical performance physical function older adults muscle strength muscle mass mediterranean diet grip strength exercise decline association
    Abstract: Background & aims: Sarcopenia is a disabling muscular multifactorial disease involving the oxidation process in old-young adults. We aimed to evaluate the relationship between antioxidant-rich foods (A-RF) and sarcopenia (muscle mass, strength, and function) based on observational studies (OS), and to assess the effectiveness of antioxidant interventions in ≥55-year-old adults via randomized controlled trials (RCTs). Moreover, to confirm if the OS results were in accordance with the RCTs results. Methods: We searched in the MEDLINE®/PubMed, Cochrane Library, and CINAHL databases from 2000 to 2020 about sarcopenia and specific nutrients/foods. The risk of bias was assessed and meta-analyses were performed using the Review Manager program. Results: The systematic review included 28 studies (19 OS, 9 RCTs), whereas the meta-analysis included 4 RCTs. Results of the systematic review of OS revealed that higher A-RF consumption was associated with better sarcopenia outcomes. Results of the RCTs meta-analysis indicated that higher fruit/vegetable consumption, supplementation with magnesium, and vitamin E plus vitamin D and protein significantly reduced the time to complete 5 stands (mean difference; 95% CI; −1.11 s; 1.70, −0.51; p < 0.01). Additionally, including tea catechin supplementation significantly increased handgrip strength (1.02 kg; 0.60, 1.44; p < 0.01). Conclusions: In sum, A-RF or antioxidant supplementation could be effective tools for sarcopenia, especially improving muscle strength and function. The best interventions according to the meta-analysis of the RCTs were supplementation of vitamin E in combination with vitamin D and protein, magnesium, tea catechins, and increasing fruit and vegetable consumption. Registration number: PROSPERO (CRD42020183045).
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: elisabet.llaurado@urv.cat mariadelaserra.besora@urv.cat anna.pedret@urv.cat rosa.sola@urv.cat mariadelaserra.besora@urv.cat
    Author identifier: 0000-0002-7439-9531 0000-0002-4375-0026 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-4375-0026
    Record's date: 2023-10-21
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0261561422002801
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Nutrition. 41 (10): 2308-2324
    APA: Besora-Moreno M; Llauradó E; Valls RM; Tarro L; Pedret A; Solà R (2022). Antioxidant-rich foods, antioxidant supplements, and sarcopenia in old-young adults ≥55 years old: A systematic review and meta-analysis of observational studies and randomized controlled trials. Clinical Nutrition, 41(10), 2308-2324. DOI: 10.1016/j.clnu.2022.07.035
    Article's DOI: 10.1016/j.clnu.2022.07.035
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Sarcopenia
    Physical function
    Older adults
    Muscle strength
    Muscle mass
    Healthy elderly-women
    Antioxidants
    vitamin-e
    skeletal-muscle
    sarcopenia
    physical performance
    physical function
    older adults
    muscle strength
    muscle mass
    mediterranean diet
    grip strength
    exercise
    decline
    association
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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