Articles producció científica> Bioquímica i Biotecnologia

Nut consumption is associated with a shift of the NMR lipoprotein subfraction profile to a less atherogenic pattern among older individuals at high CVD risk

  • Identification data

    Identifier: imarina:9282007
  • Authors:

    Garcia-Gavilan, Jesus F.
    Connelly, Margery A.
    Babio, Nancy
    Matzoros, Christos S.
    Ros, Emilio
    Salas-Salvado, Jordi
  • Others:

    Author, as appears in the article.: Garcia-Gavilan, Jesus F.; Connelly, Margery A.; Babio, Nancy; Matzoros, Christos S.; Ros, Emilio; Salas-Salvado, Jordi;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Salas Salvadó, Jorge
    Keywords: Walnuts Size Questionnaire Nuts Metabolomics Insulin-resistance Disease Advanced lipoprotein
    Abstract: Background: Scientific evidence has accumulated on the beneficial effects of nut consumption on cardiovascular risk and cholesterol reduction, but few studies have examined the effects of nuts on advanced measures of lipoprotein atherogenicity determined by nuclear magnetic resonance (NMR) spectroscopy. We analyzed associations between the amount and type of of nuts consumed and advanced measures of lipoprotein atherogenity and insulin resistance in older individuals at high cardiovascular risk.Methods: The present observational study was carried out within the framework of the Prevention con Dieta Mediterranea (PREDIMED) trial. Cross-sectional and longitudinal analyses after 1-year of follow-up were conducted in 196 men and women recruited in the PREDIMED-Reus (Spain) center. Dietary intake was assessed using a validated semiquantitative food questionnaire. Baseline and 1-year fasting plasma lipoprotein and metabolite profiling were performed in plasma using NMR spectra Vantera (R) Clinical Analyzer. Associations by tertiles of nut consumption between baseline and 1-year changes and advanced measures of lipoprotein atherogenicity, branched chain amminoacids, and measures of insulin resistance were tested by multivariable-adjusted ANCOVA models.Results: Compared to paticipants in the bottom tertile, those in the top tertile of total nut consumption showed higher levels of large HDL particles and HDL-cholesterol, lower levels of branched-chain amino acids (BCAA) and GlycA, and reduced lipoprotein insulin resistance and diabetes risk index. Participants in the top tertile of walnut consumption disclosed lower levels of very large VLDL, total LDL particles, LDL-cholesterol, and GlycA. Participants in the top tertile of non-walnut nut consumption displayed higher levels of total HDL particles, HDL-cholesterol and apoliporotein A1, lower BCAA and GlycA, and reduced lipoprotein insulin resistance. Participants in the top tertile of 1-year changes in walnut consumption showed increases in medium-sized HDL particles in comparison to the bottom tertile.Conclusions: In older individuals at high cardiovascular risk, increasing nut consumption was associated with a shift of the NMR lipoprotein subfraction profile to a less atherogenic pattern, as well as lower circulating concentrations of BCAA and decreased insulin resistance. These results provide novel mechanistic insight into the cardiovascular benefit of nut consumption.
    Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jesusfrancisco.garcia@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat jesusfrancisco.garcia@urv.cat
    Author identifier: 0000-0003-3527-5277 0000-0003-2700-7459
    Record's date: 2024-01-13
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://cardiab.biomedcentral.com/articles/10.1186/s12933-022-01624-3
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Cardiovascular Diabetology. 21 (1): 189-
    APA: Garcia-Gavilan, Jesus F.; Connelly, Margery A.; Babio, Nancy; Matzoros, Christos S.; Ros, Emilio; Salas-Salvado, Jordi; (2022). Nut consumption is associated with a shift of the NMR lipoprotein subfraction profile to a less atherogenic pattern among older individuals at high CVD risk. Cardiovascular Diabetology, 21(1), 189-. DOI: 10.1186/s12933-022-01624-3
    Article's DOI: 10.1186/s12933-022-01624-3
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Walnuts
    Size
    Questionnaire
    Nuts
    Metabolomics
    Insulin-resistance
    Disease
    Advanced lipoprotein
    Saúde coletiva
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
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