Author, as appears in the article.: Miguéns-Gómez A; Sierra-Cruz M; Pérez-Vendrell AM; Rodríguez-Gallego E; Beltrán-Debón R; Terra X; Ardévol A; Pinent M
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Keywords: High-fat diet procyanidins intestinal inflammation histomorphology gut microbiota growth-performance glucagon-like peptide-1 ghrelin fermentation
Abstract: Grape seed derived procyanidins (GSPE) have been shown to effectively prevent intestinal disarrangements induced by a cafeteria diet in young rats. However, little is known about the effects of procyanidins and cafeteria diet on enterohormone secretion in aged rats, as the ageing processes modify these effects. To study these effects in aged rats, we subjected 21-month-old and young 2-month-old female rats to two sub-chronic preventive GSPE treatments. After three months of cafeteria diet administration, we analysed the basal and stimulated secretion and mRNA expression of CCK, PYY and GLP-1, caecal SCFA and intestinal sizes. We found that the effects of a cafeteria diet on the basal duodenal CCK secretion are age dependent. GLP-1 in the ileum was not modified regardless of the rat's age, and GSPE preventive effects differed in the two age groups. GSPE pre-treatment reduced GLP-1, PYY and ChgA in mRNA in aged ileum tissue, while the cafeteria diet increased these in aged colon. The GSPE treatments only modified low-abundance SCFAs. The cafeteria diet in aged rats increases the caecum size differently from that in young rats and GSPE pre-treatment prevents this increase. Therefore, ageing modifies nutrient sensing, and the cafeteria diet acts mainly on the duodenum and colon, while procyanidins have a larger effect on the ileum.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: raul.beltran@urv.cat montserrat.pinent@urv.cat ximena.terra@urv.cat anna.ardevol@urv.cat
Author identifier: 0000-0001-9691-1906 0000-0003-3550-5378 0000-0003-1043-5844 0000-0003-0156-7538
Record's date: 2024-06-22
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2022/fo/d2fo02111k
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food & Function. 13 (20): 10491-10500
APA: Miguéns-Gómez A; Sierra-Cruz M; Pérez-Vendrell AM; Rodríguez-Gallego E; Beltrán-Debón R; Terra X; Ardévol A; Pinent M (2022). Differential effects of a cafeteria diet and GSPE preventive treatments on the enterohormone secretions of aged vs. young female rats. Food & Function, 13(20), 10491-10500. DOI: 10.1039/d2fo02111k
Article's DOI: 10.1039/d2fo02111k
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV