Articles producció científica> Bioquímica i Biotecnologia

Differential effects of a cafeteria diet and GSPE preventive treatments on the enterohormone secretions of aged vs. young female rats

  • Identification data

    Identifier: imarina:9282025
    Authors:
    Miguéns-Gómez ASierra-Cruz MPérez-Vendrell AMRodríguez-Gallego EBeltrán-Debón RTerra XArdévol APinent M
    Abstract:
    Grape seed derived procyanidins (GSPE) have been shown to effectively prevent intestinal disarrangements induced by a cafeteria diet in young rats. However, little is known about the effects of procyanidins and cafeteria diet on enterohormone secretion in aged rats, as the ageing processes modify these effects. To study these effects in aged rats, we subjected 21-month-old and young 2-month-old female rats to two sub-chronic preventive GSPE treatments. After three months of cafeteria diet administration, we analysed the basal and stimulated secretion and mRNA expression of CCK, PYY and GLP-1, caecal SCFA and intestinal sizes. We found that the effects of a cafeteria diet on the basal duodenal CCK secretion are age dependent. GLP-1 in the ileum was not modified regardless of the rat's age, and GSPE preventive effects differed in the two age groups. GSPE pre-treatment reduced GLP-1, PYY and ChgA in mRNA in aged ileum tissue, while the cafeteria diet increased these in aged colon. The GSPE treatments only modified low-abundance SCFAs. The cafeteria diet in aged rats increases the caecum size differently from that in young rats and GSPE pre-treatment prevents this increase. Therefore, ageing modifies nutrient sensing, and the cafeteria diet acts mainly on the duodenum and colon, while procyanidins have a larger effect on the ileum.
  • Others:

    Author, as appears in the article.: Miguéns-Gómez A; Sierra-Cruz M; Pérez-Vendrell AM; Rodríguez-Gallego E; Beltrán-Debón R; Terra X; Ardévol A; Pinent M
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
    Keywords: Rna, messenger Rats, wistar Rats Proanthocyanidins High-fat diet Grape seed extract Glucagon-like peptide 1 Female Diet Animals procyanidins intestinal inflammation histomorphology gut microbiota growth-performance glucagon-like peptide-1 ghrelin fermentation
    Abstract: Grape seed derived procyanidins (GSPE) have been shown to effectively prevent intestinal disarrangements induced by a cafeteria diet in young rats. However, little is known about the effects of procyanidins and cafeteria diet on enterohormone secretion in aged rats, as the ageing processes modify these effects. To study these effects in aged rats, we subjected 21-month-old and young 2-month-old female rats to two sub-chronic preventive GSPE treatments. After three months of cafeteria diet administration, we analysed the basal and stimulated secretion and mRNA expression of CCK, PYY and GLP-1, caecal SCFA and intestinal sizes. We found that the effects of a cafeteria diet on the basal duodenal CCK secretion are age dependent. GLP-1 in the ileum was not modified regardless of the rat's age, and GSPE preventive effects differed in the two age groups. GSPE pre-treatment reduced GLP-1, PYY and ChgA in mRNA in aged ileum tissue, while the cafeteria diet increased these in aged colon. The GSPE treatments only modified low-abundance SCFAs. The cafeteria diet in aged rats increases the caecum size differently from that in young rats and GSPE pre-treatment prevents this increase. Therefore, ageing modifies nutrient sensing, and the cafeteria diet acts mainly on the duodenum and colon, while procyanidins have a larger effect on the ileum.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0003-3550-5378 0000-0001-9691-1906
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2022/fo/d2fo02111k
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food & Function. 13 (20): 10491-10500
    APA: Miguéns-Gómez A; Sierra-Cruz M; Pérez-Vendrell AM; Rodríguez-Gallego E; Beltrán-Debón R; Terra X; Ardévol A; Pinent M (2022). Differential effects of a cafeteria diet and GSPE preventive treatments on the enterohormone secretions of aged vs. young female rats. Food & Function, 13(20), 10491-10500. DOI: 10.1039/d2fo02111k
    Article's DOI: 10.1039/d2fo02111k
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Food Science,Food Science & Technology,Medicine (Miscellaneous)
    Rna, messenger
    Rats, wistar
    Rats
    Proanthocyanidins
    High-fat diet
    Grape seed extract
    Glucagon-like peptide 1
    Female
    Diet
    Animals
    procyanidins
    intestinal inflammation
    histomorphology
    gut microbiota
    growth-performance
    glucagon-like peptide-1
    ghrelin
    fermentation
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
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