Articles producció científica> Bioquímica i Biotecnologia

Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders

  • Identification data

    Identifier: imarina:9282026
    Authors:
    Olloquequi, JordiCano, AmandaSanchez-Lopez, ElenaCarrasco, MarinaVerdaguer, EsterFortuna, AnaFolch, JaumeBullo, MonicaAuladell, CarmeCamins, AntoniEttcheto, Miren
    Abstract:
    Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and receptor-associated tyrosine kinases. This widely localized enzyme has been involved in the pathophysiology of several diseases. More recently, PTP1B has attracted attention in the field of neuroscience, since its activation in brain cells can lead to schizophrenia-like behaviour deficits, anxiety-like effects, neurodegeneration, neuroinflammation and depression. Conversely, PTP1B inhibition has been shown to prevent microglial activation, thus exerting a potent anti-inflammatory effect and has also shown potential to increase the cognitive process through the stimulation of hippocampal insulin, leptin and BDNF/TrkB receptors. Notwithstanding, most research on the clinical efficacy of targeting PTP1B has been developed in the field of obesity and type 2 diabetes mellitus (TD2M). However, despite the link existing between these metabolic alterations and neurodegeneration, no clinical trials assessing the neurological advantages of PTP1B inhibition have been performed yet. Preclinical studies, though, have provided strong evidence that targeting PTP1B could allow to reach different pathophysiological mechanisms at once. herefore, specific interventions or trials should be designed to modulate PTP1B activity in brain, since it is a promising strategy to decelerate or prevent neurodegeneration in aged individuals, among other neurological diseases. The present paper fails to include all neurological conditions in which PTP1B could have a role; instead, it focuses on those which have been related to metabolic alterations and neurodegenerative processes. Moreover, only preclinical data is discussed, since clinical studies on the potenti
  • Others:

    Author, as appears in the article.: Olloquequi, Jordi; Cano, Amanda; Sanchez-Lopez, Elena; Carrasco, Marina; Verdaguer, Ester; Fortuna, Ana; Folch, Jaume; Bullo, Monica; Auladell, Carme; Camins, Antoni; Ettcheto, Miren
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Folch Lopez, Jaume
    Keywords: Type 2 diabetes Ptp1b Neurological disorders Neuroinflammation Neurodegenerative diseases Insulin receptor Brain insulin-resistance Alzheimer’s disease Alzheimer's disease ursolic acid type 2 diabetes nigrostriatal tissue neurotrophic factor neurological disorders neuroinflammation neurodegenerative diseases liver-specific deletion insulin receptor improves neurobehavioral activity high-fat diet endoplasmic-reticulum stress cognitive deficits alzheimers-disease alzheimer ? s disease
    Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and receptor-associated tyrosine kinases. This widely localized enzyme has been involved in the pathophysiology of several diseases. More recently, PTP1B has attracted attention in the field of neuroscience, since its activation in brain cells can lead to schizophrenia-like behaviour deficits, anxiety-like effects, neurodegeneration, neuroinflammation and depression. Conversely, PTP1B inhibition has been shown to prevent microglial activation, thus exerting a potent anti-inflammatory effect and has also shown potential to increase the cognitive process through the stimulation of hippocampal insulin, leptin and BDNF/TrkB receptors. Notwithstanding, most research on the clinical efficacy of targeting PTP1B has been developed in the field of obesity and type 2 diabetes mellitus (TD2M). However, despite the link existing between these metabolic alterations and neurodegeneration, no clinical trials assessing the neurological advantages of PTP1B inhibition have been performed yet. Preclinical studies, though, have provided strong evidence that targeting PTP1B could allow to reach different pathophysiological mechanisms at once. herefore, specific interventions or trials should be designed to modulate PTP1B activity in brain, since it is a promising strategy to decelerate or prevent neurodegeneration in aged individuals, among other neurological diseases. The present paper fails to include all neurological conditions in which PTP1B could have a role; instead, it focuses on those which have been related to metabolic alterations and neurodegenerative processes. Moreover, only preclinical data is discussed, since clinical studies on the potential of PTP1B inhibition for treating neurological diseases are still required.Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
    Thematic Areas: Saúde coletiva Química Pharmacology & pharmacy Pharmacology Odontología Medicine, research & experimental Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iii Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.bullo@urv.cat jaume.folch@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0002-5051-8858
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0753332222010988?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biomedicine & Pharmacotherapy. 155 113709-113709
    APA: Olloquequi, Jordi; Cano, Amanda; Sanchez-Lopez, Elena; Carrasco, Marina; Verdaguer, Ester; Fortuna, Ana; Folch, Jaume; Bullo, Monica; Auladell, Carme; (2022). Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders. Biomedicine & Pharmacotherapy, 155(), 113709-113709. DOI: 10.1016/j.biopha.2022.113709
    Article's DOI: 10.1016/j.biopha.2022.113709
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology,Pharmacology & Pharmacy
    Type 2 diabetes
    Ptp1b
    Neurological disorders
    Neuroinflammation
    Neurodegenerative diseases
    Insulin receptor
    Brain insulin-resistance
    Alzheimer’s disease
    Alzheimer's disease
    ursolic acid
    type 2 diabetes
    nigrostriatal tissue
    neurotrophic factor
    neurological disorders
    neuroinflammation
    neurodegenerative diseases
    liver-specific deletion
    insulin receptor
    improves neurobehavioral activity
    high-fat diet
    endoplasmic-reticulum stress
    cognitive deficits
    alzheimers-disease
    alzheimer ? s disease
    Saúde coletiva
    Química
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Farmacia
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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