Author, as appears in the article.: Biosca-Brull, Judit; Guardia-Escote, Laia; Blanco, Jordi; Basaure, Pia; Cabre, Maria; Sanchez-Santed, Fernando; Domingo, Jose L; Teresa Colomina, Maria
Department: Psicologia; Ciències Mèdiques Bàsiques; Bioquímica i Biotecnologia
URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Keywords: Valproic acid; Social behavior; Sex factors; Prenatal exposure delayed effects; Pregnancy; Pesticides; Mice, inbred c57bl; Mice; Male; Humans; Glutamate; Gamma-aminobutyric acid; Gaba; Female; Excitatory/inhibitory balance; Corn oil; Chlorpyrifos; Cerebellar purkinje-cells; Behavior, animal; Autism; Animals; social behavior; receptor; rat-brain; messenger-rna levels; inhibitory balance; glutamate; gene-expression; gaba; female mice; excitatory; developmental neurotoxicity; brain-regions; autism
Abstract: The balance between excitatory and inhibitory neurotransmitters is essential for proper brain development. An imbalance between these two systems has been associated with neurodevelopmental disorders. On the other hand, literature also associates the massive use of pesticides with the increase of these disorders, with a particular focus on chlorpyrifos (CPF) a world-wide used organophosphate pesticide. This study was aimed at assessing social autistic-like behaviors on mice pre or postnatally exposed to CPF (0 or 1 mg/kg/day), in both sexes. In prenatal exposure, C57BL/6J pregnant mice were exposed to CPF through the diet, between gestational days (GD) 12 and 18, while a positive control group for some autistic behaviors was exposed to valproic acid (VPA) on GD 12 and 13. To assess postnatal exposure, C57BL/6J mice were orally exposed to the vehicle (corn oil) or CPF, from postnatal days (PND) 10–15. Social behavior and gene expression analysis were assessed on PND 45. Results showed social alterations only in males prenatally treated. GABA system was upregulated in CPF-treated females, whereas an increase in both systems was observed in both treated males. These findings suggest that males are more sensitive to prenatal CPF exposure, favoring the sex bias observed in ASD.
Thematic Areas: Toxicology; Saúde coletiva; Química; Odontología; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Food science & technology; Food science; Farmacia; Ensino; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: maria.cabre@urv.cat; judit.biosca@urv.cat; judit.biosca@urv.cat; joseluis.domingo@urv.cat; jordi.blanco@urv.cat; mariateresa.colomina@urv.cat
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691522006214?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Food And Chemical Toxicology. 169 113423-
APA: Biosca-Brull, Judit; Guardia-Escote, Laia; Blanco, Jordi; Basaure, Pia; Cabre, Maria; Sanchez-Santed, Fernando; Domingo, Jose L; Teresa Colomina, Mari (2022). Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner. Food And Chemical Toxicology, 169(), 113423-. DOI: 10.1016/j.fct.2022.113423
Article's DOI: 10.1016/j.fct.2022.113423
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV