Articles producció científica> Psicologia

Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner

  • Identification data

    Identifier: imarina:9282208
    Authors:
    Biosca-Brull JGuardia-Escote LBlanco JBasaure PCabré MSánchez-Santed FDomingo JLColomina MT
    Abstract:
    The balance between excitatory and inhibitory neurotransmitters is essential for proper brain development. An imbalance between these two systems has been associated with neurodevelopmental disorders. On the other hand, literature also associates the massive use of pesticides with the increase of these disorders, with a particular focus on chlorpyrifos (CPF) a world-wide used organophosphate pesticide. This study was aimed at assessing social autistic-like behaviors on mice pre or postnatally exposed to CPF (0 or 1 mg/kg/day), in both sexes. In prenatal exposure, C57BL/6J pregnant mice were exposed to CPF through the diet, between gestational days (GD) 12 and 18, while a positive control group for some autistic behaviors was exposed to valproic acid (VPA) on GD 12 and 13. To assess postnatal exposure, C57BL/6J mice were orally exposed to the vehicle (corn oil) or CPF, from postnatal days (PND) 10–15. Social behavior and gene expression analysis were assessed on PND 45. Results showed social alterations only in males prenatally treated. GABA system was upregulated in CPF-treated females, whereas an increase in both systems was observed in both treated males. These findings suggest that males are more sensitive to prenatal CPF exposure, favoring the sex bias observed in ASD.
  • Others:

    Author, as appears in the article.: Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT
    Department: Psicologia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
    Keywords: Social behavior Glutamate Gaba Excitatory/inhibitory balance Chlorpyrifos Cerebellar purkinje-cells Autism social behavior receptor rat-brain messenger-rna levels inhibitory balance glutamate gene-expression gaba female mice excitatory developmental neurotoxicity brain-regions autism
    Abstract: The balance between excitatory and inhibitory neurotransmitters is essential for proper brain development. An imbalance between these two systems has been associated with neurodevelopmental disorders. On the other hand, literature also associates the massive use of pesticides with the increase of these disorders, with a particular focus on chlorpyrifos (CPF) a world-wide used organophosphate pesticide. This study was aimed at assessing social autistic-like behaviors on mice pre or postnatally exposed to CPF (0 or 1 mg/kg/day), in both sexes. In prenatal exposure, C57BL/6J pregnant mice were exposed to CPF through the diet, between gestational days (GD) 12 and 18, while a positive control group for some autistic behaviors was exposed to valproic acid (VPA) on GD 12 and 13. To assess postnatal exposure, C57BL/6J mice were orally exposed to the vehicle (corn oil) or CPF, from postnatal days (PND) 10–15. Social behavior and gene expression analysis were assessed on PND 45. Results showed social alterations only in males prenatally treated. GABA system was upregulated in CPF-treated females, whereas an increase in both systems was observed in both treated males. These findings suggest that males are more sensitive to prenatal CPF exposure, favoring the sex bias observed in ASD.
    Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat jordi.blanco@urv.cat mariateresa.colomina@urv.cat
    Author identifier: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0001-8016-0984 0000-0002-5619-4874
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0278691522006214?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food And Chemical Toxicology. 169 113423-
    APA: Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT (2022). Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner. Food And Chemical Toxicology, 169(), 113423-. DOI: 10.1016/j.fct.2022.113423
    Article's DOI: 10.1016/j.fct.2022.113423
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Social behavior
    Glutamate
    Gaba
    Excitatory/inhibitory balance
    Chlorpyrifos
    Cerebellar purkinje-cells
    Autism
    social behavior
    receptor
    rat-brain
    messenger-rna levels
    inhibitory balance
    glutamate
    gene-expression
    gaba
    female mice
    excitatory
    developmental neurotoxicity
    brain-regions
    autism
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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