Author, as appears in the article.: Deepika, Deepika; Sharma, Raju Prasad; Schuhmacher, Marta; Sakhi, Amrit Kaur; Thomsen, Cathrine; Chatzi, Leda; Vafeiadi, Marina; Quentin, Joane; Slama, Remy; Grazuleviciene, Regina; Andrusaityte, Sandra; Waiblinger, Dagmar; Wright, John; Yang, Tiffany C; Urquiza, Jose; Vrijheid, Martine; Casas, Maribel; Domingo, Jose L; Kumar, Vikas
Department: Ciències Mèdiques Bàsiques Enginyeria Química
URV's Author/s: , Deepika / Domingo Roig, José Luis / Kumar, Vikas / Schuhmacher Ansuategui, Marta
Keywords: Sex-specific risk Pharmacokinetic Pediatric pbpk Endocrine disruptor Children cohort Bisphenol-a concentrations Bisphenol a values sex -specific risk protein-binding pharmacokinetics pharmacokinetic mother gender-differences exposure excretion endocrine disruptor children cohort bisphenol a
Abstract: Bisphenol A (BPA) is a widely known endocrine disruptor (ED) found in many children's products such as toys, feeding utensils, and teething rings. Recent epidemiology association studies have shown postnatal BPA exposure resulted in developing various diseases such as diabetes, obesity, and neurodegeneration, etc., later in their lives. However, little is known about its sex-specific metabolism and consequently internal exposure. The aim of this study was to develop a sex-specific pediatric physiologically based pharmacokinetic model (PBPK) for BPA to compare their toxicokinetic differences. First, the published adult PBPK model was re-validated, and then this model was extended by interpolation to incorporate pediatric sex specific physiological and biochemical parameters. We used both the classical body weight and ontogeny-based scaling approach to interpolate the metabolic process. Then, the pharmacokinetic attributes of the models using the two-scaling approach mentioned above were compared with adult model. Further, a sex-specific PBPK model with an ontogeny scaling approach was preferred to evaluate the pharmacokinetic differences. Moreover, this model was used to reconstruct the BPA exposure from two cohorts (Helix and PBAT Cohort) from 7 EU countries. The half-life of BPA was found to be almost the same in boys and girls at the same exposure levels. Our model estimated BPA children's exposure to be about 1500 times higher than the tolerable daily intake (TDI) recently set by European Food Safety Authority (EFSA) i.e., 0.04 ng/kg BW/day. The model demonstrated feasibility of extending the adult PBPK to sex-specific pediatric, thus investigate a gender-specific health risk assessment.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: vikas.kumar@urv.cat deepika@urv.cat deepika@urv.cat joseluis.domingo@urv.cat marta.schuhmacher@urv.cat
Author identifier: 0000-0002-9795-5967 0000-0001-6647-9470 0000-0003-4381-2490
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0013935122014013
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environmental Research. 215 (Pt 1): 114074-
APA: Deepika, Deepika; Sharma, Raju Prasad; Schuhmacher, Marta; Sakhi, Amrit Kaur; Thomsen, Cathrine; Chatzi, Leda; Vafeiadi, Marina; Quentin, Joane; Slama (2022). Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model. Environmental Research, 215(Pt 1), 114074-. DOI: 10.1016/j.envres.2022.114074
Article's DOI: 10.1016/j.envres.2022.114074
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV