Articles producció científica> Bioquímica i Biotecnologia

Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

  • Identification data

    Identifier: imarina:9282475
    Handle: https://hdl.handle.net/20.500.11797/imarina9282475
    Authors:
    Rubín-García MVitelli-Storelli FÁlvarez-álvarez LMartínez-González MÁSalas-Salvadó JCorella DHernáez ÁMartínez JAAlonso-Gómez ÁMWärnberg JVioque JRomaguera DLópez-Miranda JEstruch RTinahones FJSerra-Majem LICano-Ibañez NTur JAMarcos-Delgado ATresserra-Rimbau APintó XDelgado-Rodríguez MMatía-Martín PVidal JVázquez CDaimiel LRos EVázquez-Ruiz ZBabio NBarragán RCastañer-Niño ORazquin CTojal-Sierra LGómez-Gracia EGonzález-Palacios SMorey MGarcía-Rios ACastro-Barquero SBernal-López MRSantos-Lozano JMRuiz-Canela MCastro-Salomó APascual-Castelló ECMoldon VBullón-Vela VSorto-Sanchez CCenoz-Osinaga JCGutiérrez LMengual MLamuela-Raventós RMMartín-Sánchez V
    Abstract:
    Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic ac

  • Others:

    Author, as appears in the article.: Rubín-García M; Vitelli-Storelli F; Álvarez-álvarez L; Martínez-González MÁ; Salas-Salvadó J; Corella D; Hernáez Á; Martínez JA; Alonso-Gómez ÁM; Wärnberg J; Vioque J; Romaguera D; López-Miranda J; Estruch R; Tinahones FJ; Serra-Majem LI; Cano-Ibañez N; Tur JA; Marcos-Delgado A; Tresserra-Rimbau A; Pintó X; Delgado-Rodríguez M; Matía-Martín P; Vidal J; Vázquez C; Daimiel L; Ros E; Vázquez-Ruiz Z; Babio N; Barragán R; Castañer-Niño O; Razquin C; Tojal-Sierra L; Gómez-Gracia E; González-Palacios S; Morey M; García-Rios A; Castro-Barquero S; Bernal-López MR; Santos-Lozano JM; Ruiz-Canela M; Castro-Salomó A; Pascual-Castelló EC; Moldon V; Bullón-Vela V; Sorto-Sanchez C; Cenoz-Osinaga JC; Gutiérrez L; Mengual M; Lamuela-Raventós RM; Martín-Sánchez V
    Department: Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Castro Salomó, Antoni / Salas Salvadó, Jorge
    Keywords: Uric acid Polyphenols Hyperuricemia Food-frequency questionnaire validation uric acid polyphenols metabolic syndrome mediterranean diet mechanism inverse association health gout flavonoids coffee consumption
    Abstract: Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
    Thematic Areas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: antoni.castro@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0001-5441-6333 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.ahajournals.org/doi/10.1161/JAHA.122.026053
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of The American Heart Association. 11 (20): e026053-e026053
    APA: Rubín-García M; Vitelli-Storelli F; Álvarez-álvarez L; Martínez-González MÁ; Salas-Salvadó J; Corella D; Hernáez Á; Martínez JA; Alonso-Gómez ÁM; Wärn (2022). Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 11(20), e026053-e026053. DOI: 10.1161/JAHA.122.026053
    Article's DOI: 10.1161/JAHA.122.026053
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications

  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Uric acid
    Polyphenols
    Hyperuricemia
    Food-frequency questionnaire
    validation
    uric acid
    polyphenols
    metabolic syndrome
    mediterranean diet
    mechanism
    inverse association
    health
    gout
    flavonoids
    coffee consumption
    Saúde coletiva
    Nutrição
    Medicina ii
    Medicina i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología

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