Author, as appears in the article.: Rubin-Garcia, Maria; Vitelli-Storelli, Facundo; Alvarez-Alvarez, Laura; Martinez-Gonzalez, Miguel Angel; Salas-Salvado, Jordi; Corella, Dolores; Hernaez, Alvaro; Martinez, J Alfredo; Alonso-Gomez, Angel M; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Serra-Majem, Luis, I; Cano-Ibanez, Naomi; Tur, Josep A; Marcos-Delgado, Alba; Tresserra-Rimbau, Anna; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Vazquez-Ruiz, Zenaida; Babio, Nancy; Barragan, Rocio; Castaner-Nino, Olga; Razquin, Cristina; Tojal-Sierra, Lucas; Gomez-Gracia, Enrique; Gonzalez-Palacios, Sandra; Morey, Marga; Garcia-Rios, Antonio; Castro-Barquero, Sara; Bernal-Lopez, Maria Rosa; Santos-Lozano, Jose Manuel; Ruiz-Canela, Miguel; Castro-Salomo, Antoni; Pascual-Castello, Eva Cristina; Moldon, Veronica; Bullon-Vela, Vanessa; Sorto-Sanchez, Carolina; Cenoz-Osinaga, Juan Carlos; Gutierrez, Liliana; Mengual, Maira; Lamuela-Raventos, Rosa Maria; Martin-Sanchez, Vicente
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Castro Salomó, Antoni / Salas Salvadó, Jorge
Keywords: Uric acid Risk factors Polyphenols Male Hyperuricemia Hydroxybenzoates Humans Heart disease risk factors Food-frequency questionnaire Female Cross-sectional studies Coumaric acids Cardiovascular diseases validation uric acid polyphenols metabolic syndrome mediterranean diet mechanism inverse association health gout flavonoids coffee consumption
Abstract: Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
Thematic Areas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: antoni.castro@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0001-5441-6333 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2025-02-24
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Journal Of The American Heart Association. 11 (20): e026053-e026053
APA: Rubin-Garcia, Maria; Vitelli-Storelli, Facundo; Alvarez-Alvarez, Laura; Martinez-Gonzalez, Miguel Angel; Salas-Salvado, Jordi; Corella, Dolores; Herna (2022). Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 11(20), e026053-e026053. DOI: 10.1161/JAHA.122.026053
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV