Articles producció científica> Enginyeria Química

Control of cell-cell forces and collective cell dynamics by the intercellular adhesome

  • Identification data

    Identifier: imarina:9282544
  • Authors:

    Bazellières E
    Conte V
    Elosegui-Artola A
    Serra-Picamal X
    Bintanel-Morcillo M
    Roca-Cusachs P
    Muñoz JJ
    Sales-Pardo M
    Guimerà R
    Trepat X
  • Others:

    Author, as appears in the article.: Bazellières E; Conte V; Elosegui-Artola A; Serra-Picamal X; Bintanel-Morcillo M; Roca-Cusachs P; Muñoz JJ; Sales-Pardo M; Guimerà R; Trepat X
    Department: Enginyeria Química
    URV's Author/s: Guimera Manrique, Roger / Sales Pardo, Marta
    Keywords: Vinculin Vcl protein, human Uvomorulin Unclassified drug Small interfering rna Rna, small interfering Rna interference Regulatory mechanism Protein function Protein analysis Priority journal Physiology Phenotype P cadherin Monolayer culture Metabolism Mechanotransduction, cellular Mechanotransduction Mechanical stress Mcf10a cell line Intercellular junctions Intercellular force Intercellular adhesome Humans Human cell Human Genetics Desmosomes Desmosome Controlled study Cellular parameters Cell stimulation Cell movement Cell motion Cell migration Cell line Cell junction Cell dynamics Cell communication Cell adhesion molecule Cell adhesion Catenins Catenin Cadherins Cadherin Breast epithelium cell Article Actins Actin
    Abstract: Dynamics of epithelial tissues determine key processes in development, tissue healing and cancer invasion. These processes are critically influenced by cell-cell adhesion forces. However, the identity of the proteins that resist and transmit forces at cell-cell junctions remains unclear, and how these proteins control tissue dynamics is largely unknown. Here we provide a systematic study of the interplay between cell-cell adhesion proteins, intercellular forces and epithelial tissue dynamics. We show that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes. These phenotypes are controlled by different molecular modules and characterized by distinct relationships between cellular kinematics and intercellular forces. We show that these forces and their rates can be predicted by the concentrations of cadherins and catenins. Unexpectedly, we identified different mechanical roles for P-cadherin and E-cadherin; whereas P-cadherin predicts levels of intercellular force, E-cadherin predicts the rate at which intercellular force builds up. © 2015 Macmillan Publishers Limited.
    Thematic Areas: Medicina veterinaria Medicina i General medicine Ciências biológicas ii Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: roger.guimera@urv.cat marta.sales@urv.cat
    Author identifier: 0000-0002-3597-4310 0000-0002-8140-6525
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://www.nature.com/articles/ncb3135
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nature Cell Biology. 17 (4): 409-420
    APA: Bazellières E; Conte V; Elosegui-Artola A; Serra-Picamal X; Bintanel-Morcillo M; Roca-Cusachs P; Muñoz JJ; Sales-Pardo M; Guimerà R; Trepat X (2015). Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nature Cell Biology, 17(4), 409-420. DOI: 10.1038/ncb3135
    Article's DOI: 10.1038/ncb3135
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Cell Biology
    Vinculin
    Vcl protein, human
    Uvomorulin
    Unclassified drug
    Small interfering rna
    Rna, small interfering
    Rna interference
    Regulatory mechanism
    Protein function
    Protein analysis
    Priority journal
    Physiology
    Phenotype
    P cadherin
    Monolayer culture
    Metabolism
    Mechanotransduction, cellular
    Mechanotransduction
    Mechanical stress
    Mcf10a cell line
    Intercellular junctions
    Intercellular force
    Intercellular adhesome
    Humans
    Human cell
    Human
    Genetics
    Desmosomes
    Desmosome
    Controlled study
    Cellular parameters
    Cell stimulation
    Cell movement
    Cell motion
    Cell migration
    Cell line
    Cell junction
    Cell dynamics
    Cell communication
    Cell adhesion molecule
    Cell adhesion
    Catenins
    Catenin
    Cadherins
    Cadherin
    Breast epithelium cell
    Article
    Actins
    Actin
    Medicina veterinaria
    Medicina i
    General medicine
    Ciências biológicas ii
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
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