Articles producció científica> Bioquímica i Biotecnologia

Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease

  • Identification data

    Identifier: imarina:9283366
    Authors:
    Boronat-Toscano, AlbertMonfort-Ferre, DiandraMenacho, MargaritaCaro, AleidisBosch, RamonEspina, BeatrizAlgaba-Chueca, FranciscoSaera-Vila, AlfonsoMoline, AliciaMarti, MarcEspin, EloyMillan, MonicaSerena, Carolina
    Abstract:
    Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of visceral adipose tissue (VAT) in the inflamed intestinal area, termed creeping fat, and it is known that adipose tissue expansion influences the efficacy of anti-TNF drugs. We questioned whether anti-TNF therapies impact the creeping fat in CD, which might affect the outcome of the disease. Adipose tissue biopsies were obtained from a cohort of 14 patients with CD that received anti-TNF drugs and from 29 non-anti-TNF-treated patients (control group) matched by sex, age, and body mass index undergoing surgical interventions for symptomatic complications. We found that anti-TNF therapies restored adipose tissue morphology and suppressed immune cell infiltration in the creeping fat. Additionally, anti-TNF treatments appeared to markedly improve the pro-inflammatory phenotype of adipose-tissue macrophages and adipose-tissue-derived stem cells. Our study provides evidence that anti-TNF medications influence immune cells and progenitor cells in the creeping of patients with CD, suppressing inflammation. We propose that perilesional VAT should be considered when administering anti-TNF therapy in patients with CD.
  • Others:

    Author, as appears in the article.: Boronat-Toscano, Albert; Monfort-Ferre, Diandra; Menacho, Margarita; Caro, Aleidis; Bosch, Ramon; Espina, Beatriz; Algaba-Chueca, Francisco; Saera-Vila, Alfonso; Moline, Alicia; Marti, Marc; Espin, Eloy; Millan, Monica; Serena, Carolina;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Boronat Toscano, Albert / Bosch Príncep, Ramon / Menacho Viladot, Margarita / Monfort Ferre, Diandra / Serena Perelló, Carolina
    Keywords: Tnf Stem-cells Obesity Infliximab Immune properties Gut microbiota Diet Creeping fat Adipose tissue Adalimumab
    Abstract: Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn's disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of visceral adipose tissue (VAT) in the inflamed intestinal area, termed creeping fat, and it is known that adipose tissue expansion influences the efficacy of anti-TNF drugs. We questioned whether anti-TNF therapies impact the creeping fat in CD, which might affect the outcome of the disease. Adipose tissue biopsies were obtained from a cohort of 14 patients with CD that received anti-TNF drugs and from 29 non-anti-TNF-treated patients (control group) matched by sex, age, and body mass index undergoing surgical interventions for symptomatic complications. We found that anti-TNF therapies restored adipose tissue morphology and suppressed immune cell infiltration in the creeping fat. Additionally, anti-TNF treatments appeared to markedly improve the pro-inflammatory phenotype of adipose-tissue macrophages and adipose-tissue-derived stem cells. Our study provides evidence that anti-TNF medications influence immune cells and progenitor cells in the creeping of patients with CD, suppressing inflammation. We propose that perilesional VAT should be considered when administering anti-TNF therapy in patients with CD.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ramon.bosch@urv.cat margarita.menacho@urv.cat carolina.serena@urv.cat albert.boronat@estudiants.urv.cat diandra.monfort@estudiants.urv.cat ramon.bosch@urv.cat
    Author identifier: 0000-0003-3832-4249
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1422-0067/23/19/11170
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Molecular Sciences. 23 (19): 11170-11170
    APA: Boronat-Toscano, Albert; Monfort-Ferre, Diandra; Menacho, Margarita; Caro, Aleidis; Bosch, Ramon; Espina, Beatriz; Algaba-Chueca, Francisco; Saera-Vil (2022). Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn's Disease. International Journal Of Molecular Sciences, 23(19), 11170-11170. DOI: 10.3390/ijms231911170
    Article's DOI: 10.3390/ijms231911170
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Tnf
    Stem-cells
    Obesity
    Infliximab
    Immune properties
    Gut microbiota
    Diet
    Creeping fat
    Adipose tissue
    Adalimumab
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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