Author, as appears in the article.: Hernandez-Martinez, Carmen; Canals, Josefa; Voltas, Nuria; Martin-Lujan, Francisco; Arija, Victoria;
Department: Psicologia Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Arija Val, Maria Victoria / Canals Sans, Josefa / Hernandez Martinez, Carmen / Martín Lujan, Francisco Manuel / Voltas Moreso, Núria
Keywords: Sodium-butyrate Short chain fatty acids Propionic acid Pregnancy Neurogenesis Neurodevelopment Maternal obesity Isobutyric acid Inhibitor Infant Gut microbiota Diet Cognitive development Butyric acid Brain Autism Acetic acid
Abstract: Background: Short-chain fatty acids (SCFA) play a key role in the gut microbiota-brain crosstalk regulating the main neurodevelopmental processes during pregnancy. The aim of this study is to investigate the longitudinal relationship between prenatal levels of the main SCFAs in maternal serum and infant cognitive development and temperament on day 40 postpartum after adjusting for several pre-, peri- and post-natal confounders. Methods: A sample of 357 healthy mother-infant pairs were followed from the beginning of pregnancy to 40 days after birth. Serum SCFA concentrations were assessed in the first and third trimester of pregnancy by LC-MS/MS; and socio-demographic, nutritional, and psychological variables were collected. At 40 days, the Bayley Scales of Infant Development-III and the Early Infancy Temperament Questionnaire were administered. Results: Lower serum levels of acetic, butyric and isobutyric acid, mainly during the first trimester, were related to better language and psychomotor development and, in the case of butyric acid, better intensity behavior in infants. Medium levels of propionic acid were related to better scores for development, mood and temperament. Conclusions: These findings suggest that in a community sample of healthy pregnant women from a Mediterranean region of northern Spain, lower serum levels of SCFAs, especially in the first trimester of pregnancy, seem to be related to better infant neurodevelopment
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nuria.voltas@urv.cat paco.martin@urv.cat carmen.hernandez@urv.cat josefa.canals@urv.cat victoria.arija@urv.cat
Author identifier: 0000-0001-8855-0282 0000-0003-0359-3588 0000-0001-6328-8679 0000-0002-6209-9558 0000-0002-1758-0975
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/19/3946
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (19):
APA: Hernandez-Martinez, Carmen; Canals, Josefa; Voltas, Nuria; Martin-Lujan, Francisco; Arija, Victoria; (2022). Circulating Levels of Short-Chain Fatty Acids during Pregnancy and Infant Neurodevelopment. Nutrients, 14(19), -. DOI: 10.3390/nu14193946
Article's DOI: 10.3390/nu14193946
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV