Author, as appears in the article.: Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Maria; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Vioque, Jesus; Lopez-Miranda, Jose; Estruch, Ramon; Rosa Bernal-Lopez, M.; Lapetra, Jose; Serra-Majem, Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin Sanchez, Vicente; Pinto, Xavier; Gaforio, Jose J.; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Bes-Rastrollo, Maira; Pascual, Maria; Sorli, Jose, V; Goday, Albert; Angeles Zulet, Maria; Moreno-Rodriguez, Anai; Carmona Gonzalez, Francisco Jesus; Valls-Enguix, Rafael; Janer, Juana M.; Garcia-Rios, Antonio; Casas, Rosa; Gomez-Perez, Ana M.; Manuel Santos-Lozano, Jose; Javier Basterra-Gortari, F.; Angeles Martinez, Maria; Ortega-Azorin, Carolina; Bayo, Joan; Abete, Itziar; Salaverria-Lete, Itziar; Ruiz-Canela, Miguel; Babio, Nancy; Carres, Lourdes; Romaguera, Dora;
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Martínez Rodríguez, María Ángeles / Salas Salvadó, Jorge
Keywords: Validation Ultra-processed foods Risk Questionnaire Physical-activity Nutrition Metabolic syndrome Mediterranean diet adherence Load Liver health markers Hepatic steatosis index Glycemic index Fatty liver index Disease
Abstract: Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (beta 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mangeles.martinez@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0001-8595-3772 0000-0003-3527-5277 0000-0003-2700-7459
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/19/4142
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (19):
APA: Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Mari (2022). Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome. Nutrients, 14(19), -. DOI: 10.3390/nu14194142
Article's DOI: 10.3390/nu14194142
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV