Articles producció científica> Bioquímica i Biotecnologia

Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome

  • Identification data

    Identifier: imarina:9283375
    Authors:
    Konieczna, JadwigaFiol, MiguelColom, AntoniAngel Martinez-Gonzalez, MiguelSalas-Salvado, JordiCorella, DoloresTrinidad Soria-Florido, MariaAlfredo Martinez, J.Alonso-Gomez, Angel M.Warnberg, JuliaVioque, JesusLopez-Miranda, JoseEstruch, RamonRosa Bernal-Lopez, M.Lapetra, JoseSerra-Majem, LluisBueno-Cavanillas, AuroraTur, Josep A.Martin Sanchez, VicentePinto, XavierGaforio, Jose J.Matia-Martin, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaRos, EmilioBes-Rastrollo, MairaPascual, MariaSorli, Jose, VGoday, AlbertAngeles Zulet, MariaMoreno-Rodriguez, AnaiCarmona Gonzalez, Francisco JesusValls-Enguix, RafaelJaner, Juana M.Garcia-Rios, AntonioCasas, RosaGomez-Perez, Ana M.Manuel Santos-Lozano, JoseJavier Basterra-Gortari, F.Angeles Martinez, MariaOrtega-Azorin, CarolinaBayo, JoanAbete, ItziarSalaverria-Lete, ItziarRuiz-Canela, MiguelBabio, NancyCarres, LourdesRomaguera, Dora
    Abstract:
    Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (beta 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS.
  • Others:

    Author, as appears in the article.: Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Maria; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Vioque, Jesus; Lopez-Miranda, Jose; Estruch, Ramon; Rosa Bernal-Lopez, M.; Lapetra, Jose; Serra-Majem, Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin Sanchez, Vicente; Pinto, Xavier; Gaforio, Jose J.; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Bes-Rastrollo, Maira; Pascual, Maria; Sorli, Jose, V; Goday, Albert; Angeles Zulet, Maria; Moreno-Rodriguez, Anai; Carmona Gonzalez, Francisco Jesus; Valls-Enguix, Rafael; Janer, Juana M.; Garcia-Rios, Antonio; Casas, Rosa; Gomez-Perez, Ana M.; Manuel Santos-Lozano, Jose; Javier Basterra-Gortari, F.; Angeles Martinez, Maria; Ortega-Azorin, Carolina; Bayo, Joan; Abete, Itziar; Salaverria-Lete, Itziar; Ruiz-Canela, Miguel; Babio, Nancy; Carres, Lourdes; Romaguera, Dora;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Martínez Rodríguez, María Ángeles / Salas Salvadó, Jorge
    Keywords: Validation Ultra-processed foods Risk Questionnaire Physical-activity Nutrition Metabolic syndrome Mediterranean diet adherence Load Liver health markers Hepatic steatosis index Glycemic index Fatty liver index Disease
    Abstract: Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (beta 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: mangeles.martinez@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0001-8595-3772 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/14/19/4142
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 14 (19):
    APA: Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Mari (2022). Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome. Nutrients, 14(19), -. DOI: 10.3390/nu14194142
    Article's DOI: 10.3390/nu14194142
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Validation
    Ultra-processed foods
    Risk
    Questionnaire
    Physical-activity
    Nutrition
    Metabolic syndrome
    Mediterranean diet adherence
    Load
    Liver health markers
    Hepatic steatosis index
    Glycemic index
    Fatty liver index
    Disease
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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