Articles producció científica> Bioquímica i Biotecnologia

Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

  • Identification data

    Identifier: imarina:9283411
    Handle: https://hdl.handle.net/20.500.11797/imarina9283411
    Authors:
    Valle-Hita, CristinaBecerra-Tomas, NereaDiaz-Lopez, AndresVazquez-Ruiz, ZenaidaMegias, IsabelCorella, DoloresGoday, AlbertAlfredo Martinez, JAlonso-Gomez, Angel MWarnberg, JuliaVioque, JesusRomaguera, DoraLopez-Miranda, JoseEstruch, RamonTinahones, Francisco JLapetra, JoseSerra-Majem, LluisBueno-Cavanillas, AuroraTur, Josep AMartin-Sanchez, VicentePinto, XavierGaforio, Jose JMatia-Martin, PilarVidal, JosepAmengual-Galbarte, AngelaDaimiel, LidiaRos, EmilioGarcia-Arellano, AnaBarragan, RocioFito, MontsePena-Orihuela, Patricia JAsencio-Aznar, AlbertoGomez-Gracia, EnriqueMartinez-Urbistondo, DiegoMorey, MargaCasas, RosaMaria Garrido-Garrido, EvaTojal-Sierra, LucasDamas-Fuentes, MiguelGoni, EstibalizOrtega-Azorin, CarolinaCastaner, OlgaGarcia-Rios, AntonioGisbert-Selles, CristinaSayon-Orea, CarmenSchroder, HelmutSalas-Salvado, JordiBabio, Nancy
    Abstract:
    Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: –0.64 ml/min/1.73 m2; 95% CI: –1.21 to –0.08 and NEAP, β: –0.56 ml/min/1.73 m2; 95% CI: –1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07–1.54 and NEAP, OR: 1.24; 95% CI: 1.03–1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04–1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweig

  • Others:

    Author, as appears in the article.: Valle-Hita, Cristina; Becerra-Tomas, Nerea; Diaz-Lopez, Andres; Vazquez-Ruiz, Zenaida; Megias, Isabel; Corella, Dolores; Goday, Albert; Alfredo Martinez, J; Alonso-Gomez, Angel M; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A; Martin-Sanchez, Vicente; Pinto, Xavier; Gaforio, Jose J; Matia-Martin, Pilar; Vidal, Josep; Amengual-Galbarte, Angela; Daimiel, Lidia; Ros, Emilio; Garcia-Arellano, Ana; Barragan, Rocio; Fito, Montse; Pena-Orihuela, Patricia J; Asencio-Aznar, Alberto; Gomez-Gracia, Enrique; Martinez-Urbistondo, Diego; Morey, Marga; Casas, Rosa; Maria Garrido-Garrido, Eva; Tojal-Sierra, Lucas; Damas-Fuentes, Miguel; Goni, Estibaliz; Ortega-Azorin, Carolina; Castaner, Olga; Garcia-Rios, Antonio; Gisbert-Selles, Cristina; Sayon-Orea, Carmen; Schroder, Helmut; Salas-Salvado, Jordi; Babio, Nancy
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Díaz López, Andres / Megías Rangil, Isabel Clara / Salas Salvadó, Jorge / Valle Hita, Cristina
    Keywords: Renal nutrition Potential renal acid load (pral) Net endogenous acid production (neap) Kidney function Glomerular filtration rate (gfr) Disease progression Dietary acid load Chronic kidney disease (ckd) Albuminuria validity system risk renal nutrition potential renal acid load (pral) net endogenous acid production (neap) metaanalysis humans glomerular filtration rate (gfr) gfr endothelin dietary acid load chronic kidney disease (ckd) base load albuminuria
    Abstract: Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: –0.64 ml/min/1.73 m2; 95% CI: –1.21 to –0.08 and NEAP, β: –0.56 ml/min/1.73 m2; 95% CI: –1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07–1.54 and NEAP, OR: 1.24; 95% CI: 1.03–1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04–1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome.
    Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: isabel.megias@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat cristina.valle@alumni.urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-7500-5629 https://orcid.org/0000-0002-4429-6507 0000-0002-4429-6507 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2025-02-08
    Paper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: Front Nutr. 9 986190-
    APA: Valle-Hita, Cristina; Becerra-Tomas, Nerea; Diaz-Lopez, Andres; Vazquez-Ruiz, Zenaida; Megias, Isabel; Corella, Dolores; Goday, Albert; Alfredo Martin (2022). Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome. Front Nutr, 9(), 986190-. DOI: 10.3389/fnut.2022.986190
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications

  • Keywords:

    Endocrinology, Diabetes and Metabolism,Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Renal nutrition
    Potential renal acid load (pral)
    Net endogenous acid production (neap)
    Kidney function
    Glomerular filtration rate (gfr)
    Disease progression
    Dietary acid load
    Chronic kidney disease (ckd)
    Albuminuria
    validity
    system
    risk
    renal nutrition
    potential renal acid load (pral)
    net endogenous acid production (neap)
    metaanalysis
    humans
    glomerular filtration rate (gfr)
    gfr
    endothelin
    dietary acid load
    chronic kidney disease (ckd)
    base load
    albuminuria
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina i
    Interdisciplinar
    Food science
    Endocrinology, diabetes and metabolism
    Educação física

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