Author, as appears in the article.: Valera-Garrido F; Margalef R; Bosque M; Minaya-Muñoz F; Santafé MM
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Bosque Alberich, Marc / Santafé Martínez, Manuel
Keywords: Skeletal-muscle Percutaneous needle electrolysis Muscles injured by bupivacaine Electromyography recording Bupivacaine Axonal retractions stimulation repair rehabilitation percutaneous needle electrolysis muscles injured by bupivacaine electrotaxis electromyography recording cell bupivacaine
Abstract: Muscle regeneration after a traumatic injury can take an excessively long period of time. The purpose of this study is to assess whether the action of percutaneous needle electrolysis (PNE) accelerates muscle regeneration in cases of partial muscle injuries. The gastrocnemius muscle from adult Swiss male mice was inoculated with bupivacaine. The PNE protocol was applied 48 h after treatment with bupivacaine. Immunofluorescence techniques were performed 72 h after treatment with bupivacaine to evaluate the synaptic contacts. The end plate noise was recorded by electromyography after treatment with bupivacaine. Bupivacaine induced a local injury in muscles, axons were retracted, and the endplate noise decreased at 72 h, while the endplate noise increased in the injured limb where PNE had been applied. Seven days later, the functional values were the same as the controls and they were maintained for 10 days. The endplate noise was significantly greater on the limb treated with the electric current when compared to the limb receiving only bupivacaine, indicating that the use of galvanic current facilitated muscle regeneration at least from a functional point of view. The application of PNE during muscle regeneration in an animal model reduces the recovery time of the damaged muscle tissue.
Thematic Areas: Química Process chemistry and technology Physics, applied Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais Instrumentation General materials science General engineering Fluid flow and transfer processes Engineering, multidisciplinary Engineering (miscellaneous) Engineering (all) Engenharias ii Engenharias i Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: manuel.santafe@urv.cat
Author identifier: 0000-0002-5462-5108
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3417/12/19/10014
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Applied Sciences-Basel. 12 (19):
APA: Valera-Garrido F; Margalef R; Bosque M; Minaya-Muñoz F; Santafé MM (2022). Percutaneous Needle Electrolysis Accelerates Functional Muscle Regeneration in Mice. Applied Sciences-Basel, 12(19), -. DOI: 10.3390/app121910014
Article's DOI: 10.3390/app121910014
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV