Articles producció científica> Ciències Mèdiques Bàsiques

Percutaneous Needle Electrolysis Accelerates Functional Muscle Regeneration in Mice

  • Identification data

    Identifier: imarina:9283412
    Authors:
    Valera-Garrido FMargalef RBosque MMinaya-Muñoz FSantafé MM
    Abstract:
    Muscle regeneration after a traumatic injury can take an excessively long period of time. The purpose of this study is to assess whether the action of percutaneous needle electrolysis (PNE) accelerates muscle regeneration in cases of partial muscle injuries. The gastrocnemius muscle from adult Swiss male mice was inoculated with bupivacaine. The PNE protocol was applied 48 h after treatment with bupivacaine. Immunofluorescence techniques were performed 72 h after treatment with bupivacaine to evaluate the synaptic contacts. The end plate noise was recorded by electromyography after treatment with bupivacaine. Bupivacaine induced a local injury in muscles, axons were retracted, and the endplate noise decreased at 72 h, while the endplate noise increased in the injured limb where PNE had been applied. Seven days later, the functional values were the same as the controls and they were maintained for 10 days. The endplate noise was significantly greater on the limb treated with the electric current when compared to the limb receiving only bupivacaine, indicating that the use of galvanic current facilitated muscle regeneration at least from a functional point of view. The application of PNE during muscle regeneration in an animal model reduces the recovery time of the damaged muscle tissue.
  • Others:

    Author, as appears in the article.: Valera-Garrido F; Margalef R; Bosque M; Minaya-Muñoz F; Santafé MM
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Bosque Alberich, Marc / Santafé Martínez, Manuel
    Keywords: Skeletal-muscle Percutaneous needle electrolysis Muscles injured by bupivacaine Electromyography recording Bupivacaine Axonal retractions stimulation repair rehabilitation percutaneous needle electrolysis muscles injured by bupivacaine electrotaxis electromyography recording cell bupivacaine
    Abstract: Muscle regeneration after a traumatic injury can take an excessively long period of time. The purpose of this study is to assess whether the action of percutaneous needle electrolysis (PNE) accelerates muscle regeneration in cases of partial muscle injuries. The gastrocnemius muscle from adult Swiss male mice was inoculated with bupivacaine. The PNE protocol was applied 48 h after treatment with bupivacaine. Immunofluorescence techniques were performed 72 h after treatment with bupivacaine to evaluate the synaptic contacts. The end plate noise was recorded by electromyography after treatment with bupivacaine. Bupivacaine induced a local injury in muscles, axons were retracted, and the endplate noise decreased at 72 h, while the endplate noise increased in the injured limb where PNE had been applied. Seven days later, the functional values were the same as the controls and they were maintained for 10 days. The endplate noise was significantly greater on the limb treated with the electric current when compared to the limb receiving only bupivacaine, indicating that the use of galvanic current facilitated muscle regeneration at least from a functional point of view. The application of PNE during muscle regeneration in an animal model reduces the recovery time of the damaged muscle tissue.
    Thematic Areas: Química Process chemistry and technology Physics, applied Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais Instrumentation General materials science General engineering Fluid flow and transfer processes Engineering, multidisciplinary Engineering (miscellaneous) Engineering (all) Engenharias ii Engenharias i Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: manuel.santafe@urv.cat
    Author identifier: 0000-0002-5462-5108
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-3417/12/19/10014
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Applied Sciences-Basel. 12 (19):
    APA: Valera-Garrido F; Margalef R; Bosque M; Minaya-Muñoz F; Santafé MM (2022). Percutaneous Needle Electrolysis Accelerates Functional Muscle Regeneration in Mice. Applied Sciences-Basel, 12(19), -. DOI: 10.3390/app121910014
    Article's DOI: 10.3390/app121910014
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Chemistry, Multidisciplinary,Computer Science Applications,Engineering (Miscellaneous),Engineering, Multidisciplinary,Fluid Flow and Transfer Processes,Instrumentation,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Physics, Applied,Process Chemistry and Technology
    Skeletal-muscle
    Percutaneous needle electrolysis
    Muscles injured by bupivacaine
    Electromyography recording
    Bupivacaine
    Axonal retractions
    stimulation
    repair
    rehabilitation
    percutaneous needle electrolysis
    muscles injured by bupivacaine
    electrotaxis
    electromyography recording
    cell
    bupivacaine
    Química
    Process chemistry and technology
    Physics, applied
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Materiais
    Instrumentation
    General materials science
    General engineering
    Fluid flow and transfer processes
    Engineering, multidisciplinary
    Engineering (miscellaneous)
    Engineering (all)
    Engenharias ii
    Engenharias i
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, multidisciplinary
    Biodiversidade
    Astronomia / física
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