Repositori URV

Identifier: imarina:9283515

Handle: https://hdl.handle.net/20.500.11797/imarina9283515

Authors:
Marhuenda-Muñoz MDomínguez-López ILangohr KTresserra-Rimbau AMartínez González MÁSalas-Salvadó JCorella DZomeño MDMartínez JAAlonso-Gómez AMWärnberg JVioque JRomaguera DLópez-Miranda JEstruch RTinahones FJLapetra JSerra-Majem LBueno-Cavanillas ATur JAMartín-Sánchez VPintó XDelgado-Rodríguez MMatía-Martín PVidal JVázquez CDaimiel LRos EToledo EFernández de la Puente Cervera MBarragán RFitó MTojal-Sierra LGómez-Gracia EZazo JMMorey MGarcía-Ríos ACasas RGómez-Pérez AMSantos-Lozano JMVázquez-Ruiz ZAtzeni AAsensio EMGili-Riu MMBullon VMoreno-Rodriguez ALecea OBabio NPeñas Lopez FGómez Melis GLamuela-Raventós RM

Abstract:
Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].