Author, as appears in the article.: Garcia-Gavilan, Jesus; Nishi, Stephanie K.; Paz-Graniel, Indira; Guasch-Ferre, Marta; Razquin, Cristina; Clish, Clary B.; Toledo, Estefania; Ruiz-Canela, Miguel; Corella, Dolores; Deik, Amy; Drouin-Chartier, Jean-Philippe; Wittenbecher, Clemens; Babio, Nancy; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Liang, Liming; Martinez-Gonzalez, Miguel A.; Hu, Frank B.; Salas-Salvado, Jordi;

Department: Bioquímica i Biotecnologia

URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Nishi, Stephanie Kimiko / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge

Keywords: Type 2 diabetes Red Processed meat Predimed Physical-activity Metabolomics Metaanalysis Meat Foods Fish Diet Cardiovascular-disease Amino-acids Acylcarnitines

Abstract: Scope Consumption of meat has been associated with a higher risk of type 2 diabetes (T2D), but if plasma metabolite profiles associated with these foods reflect this relationship is unknown. The objective is to identify a metabolite signature of consumption of total meat (TM), red meat (RM), processed red meat (PRM), and fish and examine if they are associated with T2D risk. Methods and results The discovery population includes 1833 participants from the PREDIMED trial. The internal validation sample includes 1522 participants with available 1-year follow-up metabolomic data. Associations between metabolites and TM, RM, PRM, and fish are evaluated with elastic net regression. Associations between the profiles and incident T2D are estimated using Cox regressions. The profiles included 72 metabolites for TM, 69 for RM, 74 for PRM, and 66 for fish. After adjusting for T2D risk factors, only profiles of TM (Hazard Ratio (HR): 1.25, 95% CI: 1.06-1.49), RM (HR: 1.27, 95% CI: 1.07-1.52), and PRM (HR: 1.27, 95% CI: 1.07-1.51) are associated with T2D. Conclusions The consumption of TM, its subtypes, and fish is associated with different metabolites, some of which have been previously associated with T2D. Scores based on the identified metabolites for TM, RM, and PRM show a significant association with T2D risk.

Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat stephanie.nishi@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat

Author identifier: 0000-0003-3527-5277 0000-0003-2700-7459

Record's date: 2023-02-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200145

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecular Nutrition & Food Research. 66 (23): e2200145-e2200145

APA: Garcia-Gavilan, Jesus; Nishi, Stephanie K.; Paz-Graniel, Indira; Guasch-Ferre, Marta; Razquin, Cristina; Clish, Clary B.; Toledo, Estefania; Ruiz-Cane (2022). Plasma Metabolite Profiles Associated with the Amount and Source of Meat and Fish Consumption and the Risk of Type 2 Diabetes. Molecular Nutrition & Food Research, 66(23), e2200145-e2200145. DOI: 10.1002/mnfr.202200145

Article's DOI: 10.1002/mnfr.202200145

Entity: Universitat Rovira i Virgili

Journal publication year: 2022

Publication Type: Journal Publications