Author, as appears in the article.: Iftimie, Simona; Hernandez-Aguilera, Anna; Lopez-Azcona, Ana F.; Castane, Helena; Rodriguez-Tomas, Elisabet; Baiges-Gaya, Gerard; Camps, Jordi; Castro, Antoni; Joven, Jorge;
Department: Medicina i Cirurgia
URV's Author/s: Alkhoury, Nadine / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Castro Salomó, Antoni / Iftimie Iftimie, Simona Mihaela / Joven Maried, Jorge
Keywords: Urinary-tract-infection Urinary catheter Procalcitonin Player Paraoxonase-1 Kidney Inflammation Hemodialysis Galectin-3 Central venous catheter Cardiac biomarkers C-reactive protein
Abstract: Catheter-related infections (CRIs) include catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs), and they are associated with high morbidity, mortality, and healthcare costs. The diagnosis of a CRI is made difficult by its non-specific symptoms. We aimed to investigate the factors influencing the plasma concentration of galectin-3 in catheter-bearing patients and to explore its potential usefulness as an index for CRIs. Circulating the concentrations of galectin-3, we measured the chemokine (C-C) motif ligand 2, procalcitonin, and C-reactive protein in 110 patients with a central catheter, in 165 patients with a urinary catheter, and in 72 control subjects. Catheter-bearing patients had higher concentrations (p < 0.001) of galectin-3 than the control group [central catheter: 19.1 (14.0-23.4) mu g/L; urinary catheter: 17.1 (12.7-25.4) mu g/L; control group: 6.1 (5.0-8.7) mu g/L]. We identified chronic kidney disease as an independent determinant of galectin-3 concentrations in patients with a central catheter, and serum creatinine, cardiovascular disease, and number of days that the catheter was indwelling were identified as determinants in urinary catheter patients. We found that measuring galectin-3 concentrations in urinary catheter patients with a CRI was more accurate for diagnosis than the other parameters. We conclude that the measurement of galectin-3 concentration may be useful for assessing the inflammatory status of catheter-bearing patients and may contribute to the diagnosis of CRIs in those with a urinary catheter.
Thematic Areas: Medicine, general & internal Internal medicine Clinical biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: simonamihaela.iftime@urv.cat jorge.camps@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat helena.castane@estudiants.urv.cat jorge.joven@urv.cat antoni.castro@urv.cat
Author identifier: 0000-0003-0714-8414 0000-0002-3165-3640 0000-0003-2749-4541 0000-0001-5441-6333
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Diagnostics. 12 (10):
APA: Iftimie, Simona; Hernandez-Aguilera, Anna; Lopez-Azcona, Ana F.; Castane, Helena; Rodriguez-Tomas, Elisabet; Baiges-Gaya, Gerard; Camps, Jordi; Castro (2022). Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study. Diagnostics, 12(10), -. DOI: 10.3390/diagnostics12102418
Article's DOI: 10.3390/diagnostics12102418
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV