Author, as appears in the article.: Auguet, Teresa; Bertran, Laia; Barrientos-Riosalido, Andrea; Fabregat, Blanca; Villar, Beatriz; Aguilar, Carmen; Sabench, Fatima
Department: Medicina i Cirurgia
URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Sabench Pereferrer, Fàtima / Villar Navas, Beatriz
Keywords: Water pollutants, chemical Water Plastics Obesogens Non-alcoholic fatty liver disease Nanoplastics Nafld Microplastics Microbiota Lipids Humans Gut microbiota dysbiosis Animals steatohepatitis pathogenesis particles obesogens obesity nash nanoplastics nafld microbiota metabolism inflammation exposure
Abstract: Nonalcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic liver injury; however, the mechanisms underlying its progression have not been fully elucidated. Pathophysiological studies have stated that NAFLD is significantly influenced by dietary and environmental factors that could participate in the development of NAFLD through different mechanisms. Currently, “plastic pollution” is one of the most challenging environmental problems worldwide since several plastics have potential toxic or endocrine disputing properties. Specifically, the intake of microplastics (MPs) and nanoplastics (NPs) in water or diet and/or the inhalation from suspended particles is well established, and these particles have been found in human samples. Laboratory animals exposed to MPs develop inflammation, immunological responses, endocrine disruptions, and alterations in lipid and energy metabolism, among other disorders. MPs additives also demonstrated adverse reactions. There is evidence that MPs and their additives are potential “obesogens” and could participate in NAFLD pathogenesis by modifying gut microbiota composition or even worsen liver fibrosis. Although human exposure to MPs seems clear, their relationship with NAFLD requires further study, since its prevention could be a possible personalized therapeutic strategy. Adequate mitigation strategies worldwide, reducing environmental pollution and human exposure levels of MPs, could reduce the risk of NAFLD.
Thematic Areas: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andrea.barrientos@urv.cat andrea.barrientos@urv.cat beatriz.villar@urv.cat beatriz.villar@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Author identifier: 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Record's date: 2024-09-28
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1660-4601/19/20/13495
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Environmental Research And Public Health. 19 (20): 13495-
APA: Auguet, Teresa; Bertran, Laia; Barrientos-Riosalido, Andrea; Fabregat, Blanca; Villar, Beatriz; Aguilar, Carmen; Sabench, Fatima (2022). Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?. International Journal Of Environmental Research And Public Health, 19(20), 13495-. DOI: 10.3390/ijerph192013495
Article's DOI: 10.3390/ijerph192013495
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications