Author, as appears in the article.: Eraso, Arantxa; Sanz, Javier; Molla, Meritxell; Reyes, Vicky; Pedro, Agusti; Arenas, Meritxell; Martinez, Evelyn; Ballester, Rosa; Jose Cambra, Maria; Garcia, Virginia; Lluis Prades, Joan; Borras, Josep M.; Algara, Manuel;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arenas Prat, Meritxell
Keywords: Women Therapy Randomized-trial Radiotherapy Irradiation Hypofractionation Breast cancer
Abstract: Introduction Daily, moderate hypofractionation has become standard treatment for breast cancer following breast-conserving surgery, although substantial variation exists in its use. This paper describes the generation of consensus-based recommendations for the utilisation of this therapy at the healthcare system level and compares these to American Society for Radiation Oncology (ASTRO) guidelines. Materials and methods Consensus-based guidelines were developed in three steps, including a systematic literature review and involvement of radiation oncologists specialising in breast cancer in Catalonia: (a) creation of a working group and evidence review; (b) consideration of the levels of evidence and agreement on the formulation of survey questions; and (c) performance of survey and development of consensus-based recommendations. Results were compared to the ASTRO recommendations. Results Consensus was above 80% for 10 of the 14 survey items. Experts supported hypofractionated radiotherapy for all breast cancer patients aged 40 years or more; with invasive carcinoma and breast-conserving surgery; without radiation of lymph nodes; and regardless of the tumour size, histological grade, molecular subtype, breast size, laterality, other treatment characteristics, or need for a boost. Over half favoured its use in all situations, even where available scientific evidence is insufficient. The resulting recommendations and the quality of the evidence are comparable to those from ASTRO, despite some differences in the degree of consensus. Conclusion Specialists agree that hypofractionation is the standard treatment for breast cancer following breast-conserving surgery, but some specific areas require a higher level of evidence before unequivocally extending indications.
Thematic Areas: Saúde coletiva Oncology Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Farmacia Engenharias ii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: meritxell.arenas@urv.cat
Author identifier: 0000-0003-0815-2570
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://link.springer.com/article/10.1007/s12094-022-02798-8
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical & Translational Oncology. 24 (8): 1580-1587
APA: Eraso, Arantxa; Sanz, Javier; Molla, Meritxell; Reyes, Vicky; Pedro, Agusti; Arenas, Meritxell; Martinez, Evelyn; Ballester, Rosa; Jose Cambra, Maria; (2022). Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group. Clinical & Translational Oncology, 24(8), 1580-1587. DOI: 10.1007/s12094-022-02798-8
Article's DOI: 10.1007/s12094-022-02798-8
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV