Articles producció científica> Ciències Mèdiques Bàsiques

Banana peel ameliorated hepato-renal damage and exerted anti-inflammatory and anti-apoptotic effects in metal mixture mediated hepatic nephropathy by activation of Nrf2/ Hmox-1 and inhibition of Nfkb pathway

  • Identification data

    Identifier: imarina:9286856
    Authors:
    Eddie-Amadi, BFEzejiofor, ANOrish, CNRovira, JAllison, TAOrisakwe, OE
    Abstract:
    This study evaluated the protective role of banana peel extract (BP) on heavy metal mixture (HMM) mediated hepatorenal toxicity using a rat model. Twenty-five female Wistar albino rats were weight-matched and divided into five groups of five female rats each. Group 1(control) received deionized water only. Group 2 received HMM only (20 mg kg -1 of Pb, 0.40 mg kg -1 of Hg, 0.56 mg kg-1 of Mn and 35 mg kg-1 of Al). Groups 3, 4 and 5 were co-administered with the same metal mixture with BP at 200, 400 and 800 mg kg -1, respectively. Treatments were through oral gavage for 60 days; animals were sacrificed pentobarbital anesthesia and liver and kidney harvested for test. Thereafter, metal levels, malondialdehyde (MDA) and nitric oxide (NO), catalase (CAT), glutathione content (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPx), interlukin-6 (IL-6) and tumor necrosis alpha (Tnf-alpha), caspase-3 (Cas-3), Nuclear factor kappa B (Nfkb), Nuclear factor erythroid 2 -related factor 2 (Nrf2) and heme oxygenase-1 (Hmox-1) were assayed. HMM group presented higher levels of metal, IL-6 and Tnf-alpha, MDA, NO, Nfkb and Hmox-1 in HMM group which were significantly reduced by BP. BP was protective against metal mixture induced histopathological distortions. HMM exposure significantly dis-torted hepatorenal functions and BP treatment reduced metal bioavailability and abrogated most of these alterations.
  • Others:

    Author, as appears in the article.: Eddie-Amadi, BF; Ezejiofor, AN; Orish, CN; Rovira, J; Allison, TA; Orisakwe, OE
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Rovira Solano, Joaquim
    Keywords: Protective role Programmed cell death Oxidative stress Metal mixture toxicity Liver Lead Inflammation Induced neurotoxicity Hepatorenal functions Health Exposure Cadmium Banana Antioxidant Aluminum
    Abstract: This study evaluated the protective role of banana peel extract (BP) on heavy metal mixture (HMM) mediated hepatorenal toxicity using a rat model. Twenty-five female Wistar albino rats were weight-matched and divided into five groups of five female rats each. Group 1(control) received deionized water only. Group 2 received HMM only (20 mg kg -1 of Pb, 0.40 mg kg -1 of Hg, 0.56 mg kg-1 of Mn and 35 mg kg-1 of Al). Groups 3, 4 and 5 were co-administered with the same metal mixture with BP at 200, 400 and 800 mg kg -1, respectively. Treatments were through oral gavage for 60 days; animals were sacrificed pentobarbital anesthesia and liver and kidney harvested for test. Thereafter, metal levels, malondialdehyde (MDA) and nitric oxide (NO), catalase (CAT), glutathione content (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPx), interlukin-6 (IL-6) and tumor necrosis alpha (Tnf-alpha), caspase-3 (Cas-3), Nuclear factor kappa B (Nfkb), Nuclear factor erythroid 2 -related factor 2 (Nrf2) and heme oxygenase-1 (Hmox-1) were assayed. HMM group presented higher levels of metal, IL-6 and Tnf-alpha, MDA, NO, Nfkb and Hmox-1 in HMM group which were significantly reduced by BP. BP was protective against metal mixture induced histopathological distortions. HMM exposure significantly dis-torted hepatorenal functions and BP treatment reduced metal bioavailability and abrogated most of these alterations.
    Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joaquim.rovira@urv.cat
    Author identifier: 0000-0003-4399-6138
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S027869152200669X?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food And Chemical Toxicology. 170 113471-
    APA: Eddie-Amadi, BF; Ezejiofor, AN; Orish, CN; Rovira, J; Allison, TA; Orisakwe, OE (2022). Banana peel ameliorated hepato-renal damage and exerted anti-inflammatory and anti-apoptotic effects in metal mixture mediated hepatic nephropathy by activation of Nrf2/ Hmox-1 and inhibition of Nfkb pathway. Food And Chemical Toxicology, 170(), 113471-. DOI: 10.1016/j.fct.2022.113471
    Article's DOI: 10.1016/j.fct.2022.113471
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Toxicology
    Protective role
    Programmed cell death
    Oxidative stress
    Metal mixture toxicity
    Liver
    Lead
    Inflammation
    Induced neurotoxicity
    Hepatorenal functions
    Health
    Exposure
    Cadmium
    Banana
    Antioxidant
    Aluminum
    Toxicology
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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