Author, as appears in the article.: Chan, Doris S. M.; Vieira, Rita; Abar, Leila; Aune, Dagfinn; Balducci, Katia; Cariolou, Margarita; Greenwood, Darren C.; Markozannes, Georgios; Nanu, Neesha; Becerra-Tomas, Nerea; Giovannucci, Edward L.; Gunter, Marc J.; Jackson, Alan A.; Kampman, Ellen; Lund, Vivien; Allen, Kate; Brockton, Nigel T.; Croker, Helen; Katsikioti, Daphne; McGinley-Gieser, Deirdre; Mitrou, Panagiota; Wiseman, Martin; Cross, Amanda J.; Riboli, Elio; Clinton, Steven K.; McTiernan, Anne; Norat, Teresa; Tsilidis, Konstantinos K.;
Department: Bioquímica i Biotecnologia
URV's Author/s: Becerra Tomás, Nerea
Keywords: Weight change To-hip ratio Systematic review Risk-factors Receiving adjuvant chemotherapy Pathological complete response Neoadjuvant chemotherapy Mass index bmi Life-style factors Evidence grading Endocrine therapy Early-stage Disease-free survival Breast cancer survival Body fatness
Abstract: Previous evidence on postdiagnosis body fatness and mortality after breast cancer was graded as limited-suggestive. To evaluate the evidence on body mass index (BMI), waist circumference, waist-hip-ratio and weight change in relation to breast cancer prognosis, an updated systematic review was conducted. PubMed and Embase were searched for relevant studies published up to 31 October, 2021. Random-effects meta-analyses were conducted to estimate summary relative risks (RRs). The evidence was judged by an independent Expert Panel using pre-defined grading criteria. One randomized controlled trial and 225 observational studies were reviewed (220 publications). There was strong evidence (likelihood of causality: probable) that higher postdiagnosis BMI was associated with increased all-cause mortality (64 studies, 32 507 deaths), breast cancer-specific mortality (39 studies, 14 106 deaths) and second primary breast cancer (11 studies, 5248 events). The respective summary RRs and 95% confidence intervals per 5 kg/m(2) BMI were 1.07 (1.05-1.10), 1.10 (1.06-1.14) and 1.14 (1.04-1.26), with high between-study heterogeneity (I-2 = 56%, 60%, 66%), but generally consistent positive associations. Positive associations were also observed for waist circumference, waist-hip-ratio and all-cause and breast cancer-specific mortality. There was limited-suggestive evidence that postdiagnosis BMI was associated with higher risk of recurrence, nonbreast cancer deaths and cardiovascular deaths. The evidence for postdiagnosis (unexplained) weight or BMI change and all outcomes was graded as limited-no conclusion. The RCT showed potential beneficial effect of intentional weight loss on disease-free-survival, but more intervention trials and well-designed observational studies in diverse populations are needed to elucidate the impact of body composition and their changes on breast cancer outcomes.
Thematic Areas: Saúde coletiva Química Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cancer research Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nerea.becerra@urv.cat
Author identifier: 0000-0002-4429-6507
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Cancer. 152 (4): 572-599
APA: Chan, Doris S. M.; Vieira, Rita; Abar, Leila; Aune, Dagfinn; Balducci, Katia; Cariolou, Margarita; Greenwood, Darren C.; Markozannes, Georgios; Nanu, (2023). Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta-analysis. International Journal Of Cancer, 152(4), 572-599. DOI: 10.1002/ijc.34322
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV