Author, as appears in the article.: Fanelli, Giuseppe; Mota, Nina Roth; Salas-Salvado, Jordi; Bullo, Monica; Fernandez-Aranda, Fernando; Camacho-Barcia, Lucia; Testa, Giulia; Jimenez-Murcia, Susana; Bertaina-Anglade, Valerie; Franke, Barbara; Poelmans, Geert; van Gils, Veerle; Jansen, Willemijn J; Vos, Stephanie J B; Wimberley, Theresa; Dalsgaard, Soren; Barta, Csaba; Serretti, Alessandro; Fabbri, Chiara; Bralten, Janita
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: White matter integrity Reasoning Metabolism Metabolic syndrome Memory Inflammation Hypertension Executive function Diabetes mellitus Cognitive functioning Cerebrovascular-disease Body mass index Attention white matter integrity symptoms reasoning psychiatric-disorders obesity metabolic syndrome memory intelligence inflammation hypertension executive function diabetes mellitus cognitive functioning care body mass index attention association alzheimers-disease
Abstract: Clinical and genomic studies have shown an overlap between neuropsychiatric disorders and insulin resistance (IR)-related somatic conditions, including obesity, type 2 diabetes, and cardiovascular diseases. Impaired cognition is often observed among neuropsychiatric disorders, where multiple cognitive domains may be affected. In this review, we aimed to summarise previous evidence on the relationship between IR-related diseases/traits and cognitive performance in the large UK Biobank study cohort. Electronic searches were conducted on PubMed, Scopus, and Web of Science until April 2022. Eighteen articles met the inclusion criteria and were qualitatively reviewed. Overall, there is substantial evidence for an association between IR-related cardio-metabolic diseases/traits and worse performance on various cognitive domains, which is largely independent of possible confoundings. The most consistent findings referred to IR-related associations with poorer verbal and numerical reasoning ability, as well as slower processing speed. The observed associations might be mediated by alterations in immune-inflammation, brain integrity/connectivity, and/or comorbid somatic or psychiatric diseases/traits. Our findings provide impetus for further research into the underlying neurobiology and possible new therapeutic targets.
Thematic Areas: Psychology Psicología Neurosciences Neuropsychology and physiological psychology Medicina veterinaria Medicina ii Medicina i Interdisciplinar Engenharias ii Educação física Cognitive neuroscience Clinical neurology Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Behavioral sciences Behavioral neuroscience
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S014976342200416X?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Neuroscience And Biobehavioral Reviews. 143 104927-
APA: Fanelli, Giuseppe; Mota, Nina Roth; Salas-Salvado, Jordi; Bullo, Monica; Fernandez-Aranda, Fernando; Camacho-Barcia, Lucia; Testa, Giulia; Jimenez-Mur (2022). The link between cognition and somatic conditions related to insulin resistance in the UK Biobank study cohort: a systematic review. Neuroscience And Biobehavioral Reviews, 143(), 104927-. DOI: 10.1016/j.neubiorev.2022.104927
Article's DOI: 10.1016/j.neubiorev.2022.104927
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV