Author, as appears in the article.: Martínez MÁ; Marquès M; Salas-Huetos A; Babio N; Domingo JL; Salas-Salvadó J
Department: Ciències Mèdiques Bàsiques Enginyeria Electrònica, Elèctrica i Automàtica Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Domingo Roig, José Luis / Marquès Bueno, Montserrat / Martínez Rodríguez, María Ángeles / Salas Huetos, Albert / Salas Salvadó, Jorge
Keywords: Spermatozoa Sperm quality Semen Reproductive disorders Pregnancy Male fertility Male Humans Fertility Female Endocrine disruptors Endocrine disrupting chemicals
Abstract: The incidence of infertility currently affects about 15% of the world's population. Male factors are estimated to be responsible for up to 40-50% of these cases. While the cause of these reproductive disorders is still unclear, the exposure to a family of ubiquitous compounds in our daily life, named endocrine disrupting chemicals (EDCs) could be involved. This paper was aimed at performing a systematic review and meta-analysis of population studies exploring whether human male exposure to EDCs affects male fertility. Clinical and observational studies assessing the exposure to EDCs along with sperm quality, the most common reproductive disorders, sperm DNA damage, sperm oxidative stress, fertilization rate, implantation rate, clinical pregnancy rate, live birth rate, and miscarriage rate were included. The quality assessment tool from the NHLBI-NIH was used to assure that studies met standardized quality criteria. Sensitivity analysis and heterogeneity among studies was assessed. Overall, the 32 selected articles, including 7825 individuals in the systematic review, explored 12 families of EDCs. The results revealed a high heterogeneity among studies in relation to the association between exposure to EDCs and the endpoints analyzed. Meta-analyses were performed with data from 7 articles including 479 individuals, 4 articles assessing the association between BPA in urine and sperm quality, and 3 articles evaluating PCB153 in serum and sperm quality. In the meta-analysis, we identified an unpredicted significant positive association between PCB153 exposure and sperm concentration. However, it would not be clinically relevant. No positive or inverse associations were found neither for BPA, nor for PCB153 and the rest of sperm parameters analyzed. The high disparity between studies made difficult to draw conclusions on the potential harmful effects of EDCs on male fertility. Consequently, to delineate the potential relationship that EDCs can have on male fertility, an important condition stressing the health system, further investigations are required.Copyright © 2022. Published by Elsevier Inc.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: montserrat.marques@urv.cat albert.salas@urv.cat mangeles.martinez@urv.cat joseluis.domingo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0001-6302-8578 0000-0001-5914-6862 0000-0001-8595-3772 0000-0001-6647-9470 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Papper original source: Environmental Research. 217 114942-114942
APA: Martínez MÁ; Marquès M; Salas-Huetos A; Babio N; Domingo JL; Salas-Salvadó J (2023). Lack of association between endocrine disrupting chemicals and male fertility: A systematic review and meta-analysis. Environmental Research, 217(), 114942-114942. DOI: 10.1016/j.envres.2022.114942
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV