Articles producció científica> Enginyeria Química

In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario

  • Identification data

    Identifier: imarina:9287011
  • Authors:

    Esplugas R
    Linares V
    Bellés M
    Domingo JL
    Schuhmacher M
    Toxicology In Vitro
    10.1016/j.tiv.2022.105523
    Toxicology In Vitro. 87 105523-105523
  • Others:

    Author, as appears in the article.: Esplugas R; Linares V; Bellés M; Domingo JL; Schuhmacher M
    Department: Enginyeria Química Ciències Mèdiques Bàsiques
    URV's Author/s: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Esplugas Borràs, Roser / Linares Vidal, M. Victoria / Schuhmacher Ansuategui, Marta
    Keywords: Tris(1 Triphenyl phosphate (tphp) In vitro neurotoxicity Flame retardant (fr) Bis(2-ethylhexyl)tetrabromophthalate (beh-tebp) 3dichloro-2-propyl) phosphate (tdcpp) 3-dichloro-2-propyl)phosphate (tdcpp) 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (eh-tbb)
    Abstract: Since 2004, some legacy flame retardants (FRs) were restricted or removed from the European markets due to their concern on human health. Both organophosphorus FRs (OPFRs) and novel brominated FRs (NBFRs) have replaced them because they are presumably safer and less persistent emerging FRs (EFRs) and their exposure is currently occurring in indoor environments at high levels. Little is known about the neurotoxic potential risk of these EFRs in humans. The present study was aimed at assessing the acute neurotoxicity potential of Tris(1, 3dichloro-2-propyl) phosphate (TDCPP), triphenyl phosphate (TPhP), Bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) on human neuroblastoma cells (SH-SY5Y). SH-SY5Y were exposed to these EFRs at low concentrations -ranging 2.5-20 μM. during 2-24 h. We investigated viability, mitochondrial function, oxidative stress, inflammatory response, as well as neural plasticity and development. The results have demonstrated that selected EFRs (TDCPP, TPhP, EH-TBB and BEH-TBP) did not impair neural function on SH-SY5Y as acute response. To the best of our knowledge, this has been the first study focused on evaluating the neural affection of TPhP on SH-SY5Y cells and of EH-TBB and BEH-TBP on neural cells. We also assessed for the first time almost all endpoints after FR exposure on neural cell lines.Copyright © 2022. Published by Elsevier Ltd.
    Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Química Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joseluis.domingo@urv.cat mvictoria.linares@urv.cat montserrat.belles@urv.cat marta.schuhmacher@urv.cat
    Author identifier: 0000-0001-6647-9470 0000-0003-4170-4197 0000-0002-9282-2989 0000-0003-4381-2490
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0887233322002211?via%3Dihub
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Toxicology In Vitro. 87 105523-105523
    APA: Esplugas R; Linares V; Bellés M; Domingo JL; Schuhmacher M (2023). In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario. Toxicology In Vitro, 87(), 105523-105523. DOI: 10.1016/j.tiv.2022.105523
    Article's DOI: 10.1016/j.tiv.2022.105523
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Toxicology
    Tris(1
    Triphenyl phosphate (tphp)
    In vitro neurotoxicity
    Flame retardant (fr)
    Bis(2-ethylhexyl)tetrabromophthalate (beh-tebp)
    3dichloro-2-propyl) phosphate (tdcpp)
    3-dichloro-2-propyl)phosphate (tdcpp)
    2-ethylhexyl-2,3,4,5-tetrabromobenzoate (eh-tbb)
    Zootecnia / recursos pesqueiros
    Toxicology
    Química
    Odontología
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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