Author, as appears in the article.: Esplugas R; Linares V; Bellés M; Domingo JL; Schuhmacher M
Department: Enginyeria Química Ciències Mèdiques Bàsiques
URV's Author/s: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Esplugas Borràs, Roser / Linares Vidal, M. Victoria / Schuhmacher Ansuategui, Marta
Keywords: Tris(1 Triphenyl phosphate (tphp) In vitro neurotoxicity Flame retardant (fr) Bis(2-ethylhexyl)tetrabromophthalate (beh-tebp) 3dichloro-2-propyl) phosphate (tdcpp) 3-dichloro-2-propyl)phosphate (tdcpp) 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (eh-tbb)
Abstract: Since 2004, some legacy flame retardants (FRs) were restricted or removed from the European markets due to their concern on human health. Both organophosphorus FRs (OPFRs) and novel brominated FRs (NBFRs) have replaced them because they are presumably safer and less persistent emerging FRs (EFRs) and their exposure is currently occurring in indoor environments at high levels. Little is known about the neurotoxic potential risk of these EFRs in humans. The present study was aimed at assessing the acute neurotoxicity potential of Tris(1, 3dichloro-2-propyl) phosphate (TDCPP), triphenyl phosphate (TPhP), Bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) on human neuroblastoma cells (SH-SY5Y). SH-SY5Y were exposed to these EFRs at low concentrations -ranging 2.5-20 μM. during 2-24 h. We investigated viability, mitochondrial function, oxidative stress, inflammatory response, as well as neural plasticity and development. The results have demonstrated that selected EFRs (TDCPP, TPhP, EH-TBB and BEH-TBP) did not impair neural function on SH-SY5Y as acute response. To the best of our knowledge, this has been the first study focused on evaluating the neural affection of TPhP on SH-SY5Y cells and of EH-TBB and BEH-TBP on neural cells. We also assessed for the first time almost all endpoints after FR exposure on neural cell lines.Copyright © 2022. Published by Elsevier Ltd.
Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Química Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: marta.schuhmacher@urv.cat montserrat.belles@urv.cat mvictoria.linares@urv.cat joseluis.domingo@urv.cat
Author identifier: 0000-0003-4381-2490 0000-0002-9282-2989 0000-0003-4170-4197 0000-0001-6647-9470
Record's date: 2023-02-23
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0887233322002211?via%3Dihub
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Toxicology In Vitro. 87 105523-105523
APA: Esplugas R; Linares V; Bellés M; Domingo JL; Schuhmacher M (2023). In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario. Toxicology In Vitro, 87(), 105523-105523. DOI: 10.1016/j.tiv.2022.105523
Article's DOI: 10.1016/j.tiv.2022.105523
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV