Author, as appears in the article.: Castro-Barquero, S; Casas, R; Rimm, EB; Tresserra-Rimbau, A; Romaguera, D; Martínez, JA; Salas-Salvadó, J; Martínez-González, MA; Vidal, J; Ruiz-Canela, M; Konieczna, J; Sacanella, E; García-Gavilán, JF; Fitó, M; García-Arellano, A; Estruch, R
Department: Bioquímica i Biotecnologia
URV's Author/s: García Gavilán, Jesús Francisco / Salas Salvadó, Jorge
Keywords: X-ray absorptiometry Visceral adipose tissue Mediterranean diet Lifestyle Inflammation Adipokines weight-loss visceral adipose tissue risk questionnaire physical-activity obesity mediterranean diet lifestyle insulin-resistance inflammation adipose-tissue accumulation
Abstract: Excessive visceral adipose tissue (VAT) is associated with higher secretion of pro-inflammatory molecules, contributing to systemic inflammation and obesity-related metabolic disturbances.This prospective analysis includes 117 overweight/obese adults (55-75 years) from the PREDIMED-Plus study. Fourteen inflammatory markers and adipokines were measured using a Bio-Plex assay with multiplex technology: insulin, glucagon, IL-6, visfatin, ghrelin, GLP-1, TNF-α, MCP-1, PAI-1, resistin, C-peptide, leptin, adipsin and adiponectin. Participants were categorized into tertiles according to changes in VAT after 1-year of follow-up, determined by dual-energy X-Ray absorptiometry. Participants allocated in tertile 3, which represent an increase of VAT content after 1-year of follow-up compared to tertile 1, showed significant differences in insulin (T3 versus T1, fully adjusted model: p = 0.037, p for trend 0.042), PAI-1 (fully adjusted model: p = 0.05, p for trend 0.06), c-peptide (fully adjusted model: p = 0.037, p for trend 0.042), and TNF-α (fully adjusted model p = 0.037, p for trend 0.042).Our results evidenced that a reduction in VAT was associated with clinical improvements in several inflammatory and adiposity markers, mainly in insulin, c-peptide, and PAI-1 levels, and these improvements may contribute to a reduction in cardiometabolic disturbances observed in obesity. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jesusfrancisco.garcia@urv.cat jesusfrancisco.garcia@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.202200264
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 67 (4): e2200264-e2200264
APA: Castro-Barquero, S; Casas, R; Rimm, EB; Tresserra-Rimbau, A; Romaguera, D; Martínez, JA; Salas-Salvadó, J; Martínez-González, MA; Vidal, J; Ruiz-Canel (2023). Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome. Molecular Nutrition & Food Research, 67(4), e2200264-e2200264. DOI: 10.1002/mnfr.202200264
Article's DOI: 10.1002/mnfr.202200264
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV