Author, as appears in the article.: Ribas-Latre A; Santos RB; Fekry B; Tamim YM; Shivshankar S; Mohamed AMT; Baumgartner C; Kwok C; Gebhardt C; Rivera A; Gao Z; Sun K; Heiker JT; Snyder BE; Kolonin MG; Eckel-Mahan KL
Department: Medicina i Cirurgia
URV's Author/s: Ribas Latre, Aleix
Abstract: Hyperplastic expansion of white adipose tissue (WAT) relies in part on the proliferation of adipocyte precursor cells residing in the stromal vascular cell fraction (SVF) of WAT. This study reveals a circadian clock- and feeding-induced diurnal pattern of cell proliferation in the SVF of visceral and subcutaneous WAT in vivo, with higher proliferation of visceral adipocyte progenitor cells subsequent to feeding in lean mice. Fasting or loss of rhythmic feeding eliminates this diurnal proliferation, while high fat feeding or genetic disruption of the molecular circadian clock modifies the temporal expression of proliferation genes and impinges on diurnal SVF proliferation in eWAT. Surprisingly, high fat diet reversal, sufficient to reverse elevated SVF proliferation in eWAT, was insufficient in restoring diurnal patterns of SVF proliferation, suggesting that high fat diet induces a sustained disruption of the adipose circadian clock. In conclusion, the circadian clock and feeding simultaneously impart dynamic, regulatory control of adipocyte progenitor proliferation, which may be a critical determinant of adipose tissue expansion and health over time.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physics and astronomy (miscellaneous) Physics and astronomy (all) Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências General physics and astronomy General medicine General chemistry General biochemistry,genetics and molecular biology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: aleix.ribas@urv.cat
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41467-021-23770-0
Papper original source: Nature Communications. 12 (1): 3482-
APA: Ribas-Latre A; Santos RB; Fekry B; Tamim YM; Shivshankar S; Mohamed AMT; Baumgartner C; Kwok C; Gebhardt C; Rivera A; Gao Z; Sun K; Heiker JT; Snyder (2021). Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue. Nature Communications, 12(1), 3482-. DOI: 10.1038/s41467-021-23770-0
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1038/s41467-021-23770-0
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications