Articles producció científica> Bioquímica i Biotecnologia

Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome

  • Identification data

    Identifier: imarina:9287549
    Authors:
    Soldevila-Domenech NPastor ASala-Vila ALázaro IBoronat AMuñoz DCastañer OFagundo BCorella DFernández-Aranda FMartínez-González MÁSalas-Salvadó JFitó Mde la Torre R
    Abstract:
    Background: Excess circulating endocannabinoids (eCBs) and imbalanced N-acylethanolamines (NAEs) related eCBs abundance could influence dietary weight loss success. We aimed to examine sex differences in the impact of a 3-years Mediterranean diet (MedDiet) intervention on circulating eCBs, NAEs and their precursor fatty acids, and to analyze the interplay between changes in eCBs or NAEs ratios, insulin resistance and the achievement of clinically meaningful weight reductions. Methods: Prospective cohort study in a subsample of N = 105 participants (54.3% women; 65.6 ± 4.6 years) with overweight or obesity and metabolic syndrome that underwent a 3-years MedDiet intervention (PREDIMED-Plus study). Plasma eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), fatty acids, diet, glycemic homeostasis (including the assessment of insulin resistance-HOMA-IR), and cardiovascular risk markers were monitored (at 0-6-12-36 months). Results: Mediterranean diet adherence increased in both sexes and remained high during the 3 years of follow-up. Reductions in body weight, glycemic and cardiovascular parameters were larger in men than in women. Women presented higher concentrations of NAEs than men throughout the study. In both sexes, AEA and other NAEs (including OEA, and PEA) decreased after 6 months (for AEA: −4.9%), whereas the ratio OEA/AEA increased after 1 year (+5.8%). Changes in 2-AG (−3.9%) and the ratio OEA/PEA (+8.2%) persisted over the 3 years of follow-up. In women, 6-months changes in AEA (OR = 0.65) and the ratio OEA/AEA (OR = 3.28) were associated with the achievement of 8% weight reductions and correlated with HOMA-IR changes (r = 0.29 and r = −0.34). In men, OEA/PEA changes were associated
  • Others:

    Author, as appears in the article.: Soldevila-Domenech N; Pastor A; Sala-Vila A; Lázaro I; Boronat A; Muñoz D; Castañer O; Fagundo B; Corella D; Fernández-Aranda F; Martínez-González MÁ; Salas-Salvadó J; Fitó M; de la Torre R
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Weight loss Sex differences Metabolic syndrome Mediterranean diet Insulin resistance Fasting plasma-glucose Endocannabinoids Anandamide (aea) 2-arachidonoylglycerol (2-ag) weight loss system risk-factors questionnaire oleoylethanolamide obese men metabolic syndrome mediterranean diet insulin resistance homeostasis fatty-acid-composition endocannabinoids disease anandamide (aea) adipose-tissue 2-arachidonoylglycerol (2-ag)
    Abstract: Background: Excess circulating endocannabinoids (eCBs) and imbalanced N-acylethanolamines (NAEs) related eCBs abundance could influence dietary weight loss success. We aimed to examine sex differences in the impact of a 3-years Mediterranean diet (MedDiet) intervention on circulating eCBs, NAEs and their precursor fatty acids, and to analyze the interplay between changes in eCBs or NAEs ratios, insulin resistance and the achievement of clinically meaningful weight reductions. Methods: Prospective cohort study in a subsample of N = 105 participants (54.3% women; 65.6 ± 4.6 years) with overweight or obesity and metabolic syndrome that underwent a 3-years MedDiet intervention (PREDIMED-Plus study). Plasma eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), fatty acids, diet, glycemic homeostasis (including the assessment of insulin resistance-HOMA-IR), and cardiovascular risk markers were monitored (at 0-6-12-36 months). Results: Mediterranean diet adherence increased in both sexes and remained high during the 3 years of follow-up. Reductions in body weight, glycemic and cardiovascular parameters were larger in men than in women. Women presented higher concentrations of NAEs than men throughout the study. In both sexes, AEA and other NAEs (including OEA, and PEA) decreased after 6 months (for AEA: −4.9%), whereas the ratio OEA/AEA increased after 1 year (+5.8%). Changes in 2-AG (−3.9%) and the ratio OEA/PEA (+8.2%) persisted over the 3 years of follow-up. In women, 6-months changes in AEA (OR = 0.65) and the ratio OEA/AEA (OR = 3.28) were associated with the achievement of 8% weight reductions and correlated with HOMA-IR changes (r = 0.29 and r = −0.34). In men, OEA/PEA changes were associated with 8% weight reductions (OR = 2.62) and correlated with HOMA-IR changes (r = −0.32). Conclusion: A 3-years MedDiet intervention modulated plasma concentrations of eCBs and NAEs. Changes in AEA and in the relative abundance of NAEs were associated with clinically meaningful weight reductions. However, marked sex differences were identified in eCBs and NAEs, as well as in the efficacy of the intervention in terms of glycemic and cardiovascular parameters, which could be related to post-menopause alterations in glucose metabolism. These findings support a sex-balanced research strategy for a better understanding of the mechanisms underlying the regulation of body weight loss.
    Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-08-31
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fnut.2022.1076677/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Front Nutr. 9 1076677-1076677
    APA: Soldevila-Domenech N; Pastor A; Sala-Vila A; Lázaro I; Boronat A; Muñoz D; Castañer O; Fagundo B; Corella D; Fernández-Aranda F; Martínez-González MÁ; (2022). Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome. Front Nutr, 9(), 1076677-1076677. DOI: 10.3389/fnut.2022.1076677
    Article's DOI: 10.3389/fnut.2022.1076677
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology, Diabetes and Metabolism,Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Weight loss
    Sex differences
    Metabolic syndrome
    Mediterranean diet
    Insulin resistance
    Fasting plasma-glucose
    Endocannabinoids
    Anandamide (aea)
    2-arachidonoylglycerol (2-ag)
    weight loss
    system
    risk-factors
    questionnaire
    oleoylethanolamide
    obese men
    metabolic syndrome
    mediterranean diet
    insulin resistance
    homeostasis
    fatty-acid-composition
    endocannabinoids
    disease
    anandamide (aea)
    adipose-tissue
    2-arachidonoylglycerol (2-ag)
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina i
    Interdisciplinar
    Food science
    Endocrinology, diabetes and metabolism
    Educação física
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