Articles producció científica> Bioquímica i Biotecnologia

Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats

  • Identification data

    Identifier: imarina:9287554
    Authors:
    Ruiz de Azua, Ma JosefinaManocchio, FrancescaCruz-Carrion, AlvaroArola-Arnal, AnnaTorres-Fuentes, CristinaAdrian Bernal, ClaudioSain, JulianaSuarez, Manuel
    Abstract:
    Circadian and seasonal variations produce variations in physiological processes throughout the day and the year, respectively. In this sense, both the light and the moment of feeding are strong modulators of the central and peripheral clocks. However, little is known about its influence on certain metabolic parameters and on the composition of liver and muscle fatty acids (FA). In the present study, 24 Fischer 344 rats were exposed for 11 weeks to different photoperiods, L6, L12 and L18, with 6, 12 and 18 h of light/day, respectively. They were fed a standard diet. Serum metabolic parameters, gene expression of liver enzymes and gastrocnemius muscle involved in the synthesis, elongation, desaturation and β-oxidation of FA were analyzed. We have found that exposure to different hours of light has a clear effect on FA composition and gene expression in the liver. Mainly, the biosynthesis of unsaturated FA was altered in the L18 animals with respect to those exposed to L12, while the L6 did not show significant changes. At the muscle level, differences were observed in the concentration of mono and polyunsaturated FA. A multivariate analysis confirmed the differences between L12 and L18 in a significant way. We conclude that exposure to long days produces changes in the composition of liver and muscle FA, as well as changes in the gene expression of oxidative enzymes compared to exposure to L12, which could be a consequence of different seasonal eating patterns.
  • Others:

    Author, as appears in the article.: Ruiz de Azua, Ma Josefina; Manocchio, Francesca; Cruz-Carrion, Alvaro; Arola-Arnal, Anna; Torres-Fuentes, Cristina; Adrian Bernal, Claudio; Sain, Juliana; Suarez, Manuel
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Arola Arnal, Anna / Cruz Carrión, Álvaro Javier / Manocchio, Francesca / Suárez Recio, Manuel / Torres Fuentes, Cristina
    Keywords: Skeletal-muscle Seasonality Rats, inbred f344 Rats Photoperiod Muscle, skeletal Metabolism Liver Fatty acids, unsaturated Fatty acids Fatty acid profile Chrononutrition Animals seasonality rhythms physiology oxidation metabolism lipid-metabolism light fatty acid profile circadian clock cells
    Abstract: Circadian and seasonal variations produce variations in physiological processes throughout the day and the year, respectively. In this sense, both the light and the moment of feeding are strong modulators of the central and peripheral clocks. However, little is known about its influence on certain metabolic parameters and on the composition of liver and muscle fatty acids (FA). In the present study, 24 Fischer 344 rats were exposed for 11 weeks to different photoperiods, L6, L12 and L18, with 6, 12 and 18 h of light/day, respectively. They were fed a standard diet. Serum metabolic parameters, gene expression of liver enzymes and gastrocnemius muscle involved in the synthesis, elongation, desaturation and β-oxidation of FA were analyzed. We have found that exposure to different hours of light has a clear effect on FA composition and gene expression in the liver. Mainly, the biosynthesis of unsaturated FA was altered in the L18 animals with respect to those exposed to L12, while the L6 did not show significant changes. At the muscle level, differences were observed in the concentration of mono and polyunsaturated FA. A multivariate analysis confirmed the differences between L12 and L18 in a significant way. We conclude that exposure to long days produces changes in the composition of liver and muscle FA, as well as changes in the gene expression of oxidative enzymes compared to exposure to L12, which could be a consequence of different seasonal eating patterns.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Radiology, nuclear medicine and imaging Radiological and ultrasound technology Radiation Química Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biophysics Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: francesca.manocchio@urv.cat francesca.manocchio@urv.cat francesca.manocchio@urv.cat manuel.suarez@urv.cat anna.arola@urv.cat cristina.torres@urv.cat
    Author identifier: 0000-0003-0122-8253 0000-0001-6529-1345 0000-0002-2917-6910
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1011134422002366
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Photochemistry And Photobiology B-Biology. 238 112621-
    APA: Ruiz de Azua, Ma Josefina; Manocchio, Francesca; Cruz-Carrion, Alvaro; Arola-Arnal, Anna; Torres-Fuentes, Cristina; Adrian Bernal, Claudio; Sain, Juli (2023). Fatty acid metabolism in liver and muscle is strongly modulated by photoperiod in Fischer 344 rats. Journal Of Photochemistry And Photobiology B-Biology, 238(), 112621-. DOI: 10.1016/j.jphotobiol.2022.112621
    Article's DOI: 10.1016/j.jphotobiol.2022.112621
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Biophysics,Radiation,Radiological and Ultrasound Technology,Radiology, Nuclear Medicine and Imaging
    Skeletal-muscle
    Seasonality
    Rats, inbred f344
    Rats
    Photoperiod
    Muscle, skeletal
    Metabolism
    Liver
    Fatty acids, unsaturated
    Fatty acids
    Fatty acid profile
    Chrononutrition
    Animals
    seasonality
    rhythms
    physiology
    oxidation
    metabolism
    lipid-metabolism
    light
    fatty acid profile
    circadian clock
    cells
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Radiology, nuclear medicine and imaging
    Radiological and ultrasound technology
    Radiation
    Química
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biophysics
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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