Author, as appears in the article.: Tomàs J; Lanuza MA; Santafé MM; Cilleros-Mañé V; Just-Borràs L; Balanyà-Segura M; Polishchuk A; Nadal L; Tomàs M; Garcia N
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Balanya Segura, Marta / Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / POLISHCHUK, ALEKSANDRA / Santafé Martínez, Manuel / Tomás Ferré, José Maria / Tomas Marginet, Marta
Keywords: Serine kinases Protein-kinase-c Postnatal synapse elimination Muscarinic acetylcholine receptors Calcium channels Axonal competition Acetylcholine release synapse elimination skeletal-muscle serine kinases postnatal-development polyneuronal innervation perisynaptic schwann-cells neurotransmitter release muscarinic acetylcholine receptors modulate transmitter release calcium-channels calcium channels axonal competition acetylcholine-release acetylcholine release
Abstract: In recent years, we have studied by immunohistochemistry, intracellular recording, and western blotting the role of the muscarinic acetylcholine receptors (mAChRs; M1, M2, and M4 subtypes) in the mammalian neuromuscular junction (NMJ) during development and in the adult. Here, we evaluate our published data to emphasize the mAChRs’ relevance in developmental synaptic elimination and their crosstalk with other metabotropic receptors, downstream kinases, and voltage-gated calcium channels (VGCCs). The presence of mAChRs in the presynaptic membrane of motor nerve terminals allows an autocrine mechanism in which the secreted acetylcholine influences the cell itself in feedback. mAChR subtypes are coupled to different downstream pathways, so their feedback can move in a broad range between positive and negative. Moreover, mAChRs allow direct activity-dependent interaction through ACh release between the multiple competing axons during development. Additional regulation from pre- and postsynaptic sites (including neurotrophic retrograde control), the agonistic and antagonistic contributions of adenosine receptors (AR; A1 and A2A), and the tropomyosin-related kinase B receptor (TrkB) cooperate with mAChRs in the axonal competitive interactions which lead to supernumerary synapse elimination that achieves the optimized monoinnervation of musculoskeletal cells. The metabotropic receptor-driven balance between downstream PKA and PKC activities, coupled to developmentally regulated VGCC, explains much of how nerve terminals with different activities finally progress to their withdrawal or strengthening.
Thematic Areas: Saúde coletiva Química Odontología Nutrição Neurosciences Neuroscience (miscellaneous) Neurology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias iv Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Cellular and molecular neuroscience Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: victor.cilleros@urv.cat marta.balanya@urv.cat marta.tomas@urv.cat aleksandra.polishchuk@urv.cat manuel.santafe@urv.cat mariaangel.lanuza@urv.cat laia.just@urv.cat josepmaria.tomas@urv.cat victor.cilleros@urv.cat marta.balanya@urv.cat aleksandra.polishchuk@urv.cat
Author identifier: 0000-0001-5690-9932 0000-0003-0983-4944 0000-0002-4151-1697 0000-0001-6445-1538 0000-0002-5462-5108 0000-0003-4795-4103 0000-0003-0473-3730 0000-0002-0406-0006 0000-0001-5690-9932 0000-0003-0983-4944 0000-0001-6445-1538
Record's date: 2023-09-02
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://link.springer.com/article/10.1007/s12035-022-03154-1
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Neurobiology. 60 (3): 1580-1593
APA: Tomàs J; Lanuza MA; Santafé MM; Cilleros-Mañé V; Just-Borràs L; Balanyà-Segura M; Polishchuk A; Nadal L; Tomàs M; Garcia N (2023). Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction. Molecular Neurobiology, 60(3), 1580-1593. DOI: 10.1007/s12035-022-03154-1
Article's DOI: 10.1007/s12035-022-03154-1
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV