Articles producció científica> Bioquímica i Biotecnologia

Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

  • Identification data

    Identifier: imarina:9287575
    Authors:
    Bullón-Vela VXu YRazquin CAbete IZulet MAMartínez-González MABuil-Corsiales PVitelli-Storelli FMartín Sánchez VVazquez-Ruíz ZSayón-Orea CDomínguez-Fernández MCid CEstruch RLamuela-Raventós RMFitó MBlanchart GBabio NSalas-Salvadó JTinahones FJTur JARomaguera DKonieczna JPintó XDaimiel LRodriguez-Mateos AMartínez JA
    Abstract:
    Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanon
  • Others:

    Author, as appears in the article.: Bullón-Vela V; Xu Y; Razquin C; Abete I; Zulet MA; Martínez-González MA; Buil-Corsiales P; Vitelli-Storelli F; Martín Sánchez V; Vazquez-Ruíz Z; Sayón-Orea C; Domínguez-Fernández M; Cid C; Estruch R; Lamuela-Raventós RM; Fitó M; Blanchart G; Babio N; Salas-Salvadó J; Tinahones FJ; Tur JA; Romaguera D; Konieczna J; Pintó X; Daimiel L; Rodriguez-Mateos A; Martínez JA
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
    Keywords: Mediterranean diet adherence risk population orange juice naringenin flavanones disease diagnosis bioavailability (poly)phenol intake
    Abstract: Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2023/FO/D2FO02846H
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food & Function. 14 (2): 1011-1023
    APA: Bullón-Vela V; Xu Y; Razquin C; Abete I; Zulet MA; Martínez-González MA; Buil-Corsiales P; Vitelli-Storelli F; Martín Sánchez V; Vazquez-Ruíz Z; Sayón (2023). Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites. Food & Function, 14(2), 1011-1023. DOI: 10.1039/d2fo02846h
    Article's DOI: 10.1039/d2fo02846h
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Food Science,Food Science & Technology,Medicine (Miscellaneous)
    Mediterranean diet adherence
    risk
    population
    orange juice
    naringenin
    flavanones
    disease
    diagnosis
    bioavailability
    (poly)phenol intake
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
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