Author, as appears in the article.: Bullon-Vela, Vanessa; Xu, Yifan; Razquin, Cristina; Abete, Itziar; Angeles Zulet, Maria; Martinez-Gonzalez, Miguel A; Buil-Corsiales, Pilar; Vitelli-Storelli, Facundo; Martin Sanchez, Vicente; Vazquez-Ruiz, Zenaida; Sayon-Orea, Carmen; Dominguez-Fernandez, Maite; Cid, Concepcion; Estruch, Ramon; Maria Lamuela-Raventos, Rosa; Fito, Montserrat; Blanchart, Gemma; Babio, Nancy; Salas-Salvado, Jordi; Tinahones, Francisco J; Tur, Josep A; Romaguera, Dora; Konieczna, Jadwiga; Pinto, Xavier; Daimiel, Lidia; Rodriguez-Mateos, Ana; Alfredo Martinez, Jose
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Keywords: Transferases Mediterranean diet adherence Liver Inflammation Flavonoids Flavanones Cross-sectional studies Citrus risk population orange juice naringenin flavanones disease diagnosis bioavailability (poly)phenol intake
Abstract: Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Food & Function. 14 (2): 1011-1023
APA: Bullon-Vela, Vanessa; Xu, Yifan; Razquin, Cristina; Abete, Itziar; Angeles Zulet, Maria; Martinez-Gonzalez, Miguel A; Buil-Corsiales, Pilar; Vitelli-S (2023). Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites. Food & Function, 14(2), 1011-1023. DOI: 10.1039/d2fo02846h
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV