Author, as appears in the article.: Calderon-Perez, L; Companys, J; Sola, R; Pedret, A; Valls, RM
Department: Medicina i Cirurgia
URV's Author/s: Calderon Pérez, Lorena / Companys Alemany, Judit / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Sphingolipids Polyunsaturated fatty acids Lysoglycerophospholipids Lipoprotein-associated phospholipase-a2 Lipoprotein-associated phospholipase a2 Glycerophospholipids Cardiovascular disease sphingolipids profile polyunsaturated fatty acids plasma omega-3-fatty-acids obesity lysoglycerophospholipids lipoprotein-associated phospholipase a2 inflammation glycerophospholipids global burden
Abstract: Dietary fatty acids (FAs), primarily n-3 polyunsaturated FAs, have been associated with enrichment of the circulating bioactive lipidome and changes in the enzymatic precursor lipoprotein-associated phospholipase A2 (Lp-PLA2) mass; however, the magnitude of this effect remains unclear.The aim of this systematic review and meta-analysis was to evaluate the effect of different dietary FAs on the bioactive lipid profile of healthy participants and those with cardiovascular disease (CVD) and CVD risk factors.PubMed, SCOPUS and the Cochrane Library databases were searched for relevant articles published between October 2010 and May 2022.Data were screened for relevance and then retrieved in full and evaluated for eligibility by 2 reviewers independently.The net difference in the bioactive lipid mean values between the endpoint and the baseline, and the corresponding SDs or SEs, were used for the qualitative synthesis. For the meta-analysis, a fixed-effects model was used.Twenty-seven randomized clinical trials (representing >2560 participants) were included. Over 78% of the enrolled participants had ≥1 associated CVD risk factor, whereas <22% were healthy. In the meta-analysis, marine n-3 supplements (dose range, 0.37-1.9 g/d) significantly increased pro-inflammatory lysophosphatidylcholines (lyso-PCs; for lyso-PC(16:0): mean, +0.52 [95% confidence interval (CI), 0.02-1.01] µM; for lyso-PC(18:0): mean, +0.58 [95%CI, 0.09-1.08] µM) in obese participants. Additionally, n-3 supplementation (1-5.56 g/d) decreased plasma Lp-PLA2 mass, a well-known inflammation marker, in healthy (-0.35 [95%CI, -0.59 to -0.10] ng/mL), dyslipidemic (-0.36 [95%CI, -0.47 to -0.25] ng/mL), and stable coronary artery disease participants (-0.52 [95%CI, -0.91 to -0.12] ng/mL).Daily n-3 provided as EPA+DHA supplements and consumed from 1 to 6 months reduced plasma Lp-PLA2 mass in healthy participants and those with CVD and CVD risk factors, suggesting an anti-inflammatory effect. However, the saturated lyso-PC response to n-3 was impaired in obese participants.PROSPERO registration no. CRD42021218335.© The Author(s) 2022. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: lorena.calderon@urv.cat judit.companys@urv.cat anna.pedret@urv.cat judit.companys@urv.cat judit.companys@urv.cat lorena.calderon@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat
Author identifier: 0000-0003-0766-0733 0000-0003-1485-0818 0000-0002-5327-932X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-3351-0942 0000-0002-8359-235X
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrition Reviews. 81 (8): 988-1033
APA: Calderon-Perez, L; Companys, J; Sola, R; Pedret, A; Valls, RM (2023). The effects of fatty acid-based dietary interventions on circulating bioactive lipid levels as intermediate biomarkers of health, cardiovascular disease, and cardiovascular disease risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition Reviews, 81(8), 988-1033. DOI: 10.1093/nutrit/nuac101
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV