Articles producció científica> Medicina i Cirurgia

Combining Dietary Intervention with Metformin Treatment Enhances Non-Alcoholic Steatohepatitis Remission in Mice Fed a High-Fat High-Sucrose Diet

  • Identification data

    Identifier: imarina:9287631
    Authors:
    Baiges-Gaya GRodríguez-Tomàs ECastañé HJiménez-Franco AAmigó NCamps JJoven J
    Abstract:
    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which lifestyle interventions are the only effective first-line treatment. Dietary interventions are effective in body weight reduction, but not in improving insulin sensitivity and hepatic lipid mobilization. Conversely, metformin increases insulin sensitivity and promotes the inhibition of de novo hepatic lipogenesis. In this study, we evaluated the metformin effectiveness in NASH prevention and treatment, when combined with dietary intervention in male mice fed a high-fat high-sucrose diet (HFHSD). Eighty 5-week-old C57BL/6J male mice were fed a chow or HFHSD diet and sacrificed at 20 or 40 weeks. The HFHSD-fed mice developed NASH after 20 weeks. Lipoprotein and lipidomic analyses showed that the changes associated with diet were not prevented by metformin administration. HFHSD-fed mice subject to dietary intervention combined with metformin showed a 19.6% body weight reduction compared to 9.8% in those mice subjected to dietary intervention alone. Lower hepatic steatosis scores were induced. We conclude that metformin should not be considered a preventive option for NAFLD, but it is effective in the treatment of this disorder when combined with dietary intervention.
  • Others:

    Author, as appears in the article.: Baiges-Gaya G; Rodríguez-Tomàs E; Castañé H; Jiménez-Franco A; Amigó N; Camps J; Joven J
    Department: Medicina i Cirurgia
    URV's Author/s: Camps Andreu, Jorge / Joven Maried, Jorge
    Keywords: Obesity Nafld Mice Liver Lipidomic Hepatic steatosis Adipose tissue therapy phosphatidylcholine obese nafld mice metabolism liver lipidomic insulin-binding induction deficiency autophagy adipose tissue
    Abstract: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which lifestyle interventions are the only effective first-line treatment. Dietary interventions are effective in body weight reduction, but not in improving insulin sensitivity and hepatic lipid mobilization. Conversely, metformin increases insulin sensitivity and promotes the inhibition of de novo hepatic lipogenesis. In this study, we evaluated the metformin effectiveness in NASH prevention and treatment, when combined with dietary intervention in male mice fed a high-fat high-sucrose diet (HFHSD). Eighty 5-week-old C57BL/6J male mice were fed a chow or HFHSD diet and sacrificed at 20 or 40 weeks. The HFHSD-fed mice developed NASH after 20 weeks. Lipoprotein and lipidomic analyses showed that the changes associated with diet were not prevented by metformin administration. HFHSD-fed mice subject to dietary intervention combined with metformin showed a 19.6% body weight reduction compared to 9.8% in those mice subjected to dietary intervention alone. Lower hepatic steatosis scores were induced. We conclude that metformin should not be considered a preventive option for NAFLD, but it is effective in the treatment of this disorder when combined with dietary intervention.
    Thematic Areas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat
    Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2218-273X/12/12/1787
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biomolecules. 12 (12):
    APA: Baiges-Gaya G; Rodríguez-Tomàs E; Castañé H; Jiménez-Franco A; Amigó N; Camps J; Joven J (2022). Combining Dietary Intervention with Metformin Treatment Enhances Non-Alcoholic Steatohepatitis Remission in Mice Fed a High-Fat High-Sucrose Diet. Biomolecules, 12(12), -. DOI: 10.3390/biom12121787
    Article's DOI: 10.3390/biom12121787
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Molecular Biology
    Obesity
    Nafld
    Mice
    Liver
    Lipidomic
    Hepatic steatosis
    Adipose tissue
    therapy
    phosphatidylcholine
    obese
    nafld
    mice
    metabolism
    liver
    lipidomic
    insulin-binding
    induction
    deficiency
    autophagy
    adipose tissue
    Química
    Molecular biology
    Materiais
    General medicine
    Farmacia
    Ensino
    Biochemistry & molecular biology
    Biochemistry
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